Senior Principal Scientist, Translational Clinical Biomarkers

MSD

Senior Principal Scientist providing strategic leadership in clinical biomarker strategies for immune-mediated therapeutics. Driving decision-centric biomarker approaches across the development lifecycle in a fast-paced environment.

Posted 5/27/2026full-timeRahway • Massachusetts, New Jersey, Pennsylvania • 🇺🇸 United StatesSenior💰 $210,400 - $331,100 per yearWebsite

About the role

Key responsibilities & impact

Provide strategic and scientific leadership in the design, execution, analysis, and communication of clinical biomarker strategies across immune-mediated therapeutic portfolio
Drive decision-centric biomarker strategies that connect drug mechanism, disease biology, precision medicine
Lead and shape integrated biomarker strategies across discovery, early- and late-stage clinical programs
Serve as the biomarker strategy lead within cross-functional program teams
Inform portfolio strategy by advancing biomarker-driven insights
Translate disease biology into clinically actionable biomarker strategies
Drive selection and application of innovative biomarker approaches
Collaborate effectively across disciplines to integrate scientific perspectives into cohesive strategies
Champion biomarker analysis plans and provide critical scientific input to interpretation of complex datasets

Requirements

What you’ll need

Ph.D. or M.D. with 12+ years in Immunology or related scientific discipline
Deep expertise in immunology and immune-mediated/inflammatory diseases
Experience in at least one of the following: Gastrointestinal/mucosal inflammation, Rheumatology, Dermatology
Proven track record of driving translational strategies that inform clinical development decisions
Strong analytical and problem-solving capabilities
Excellent communication skills, including experience presenting to senior leadership
Working knowledge with biostatistics, bioinformatics, and advanced data analytics
Strategic mindset with a focus on decision impact rather than data generation alone
Proven ability to operate effectively in a fast-moving, matrixed environment

Benefits

Comp & perks

medical, dental, vision healthcare and other insurance benefits (for employee and family)
retirement benefits, including 401(k)
paid holidays
vacation
compassionate and sick days

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

biomarker strategiesimmunologybiostatisticsbioinformaticsdata analyticstranslational strategiesclinical developmentdisease biologybiomarker analysisclinical programs

Soft Skills

strategic leadershipanalytical capabilitiesproblem-solvingcommunication skillscollaborationdecision-makingpresentation skillscross-functional teamworkadaptabilitycritical thinking

Certifications

Ph.D.M.D.