Senior Applied Scientist
Motive
PySparkPythonSQL
Principal Scientist, Drug Metabolism and Pharmacokinetics
MSD
full-time
Posted on:
Location Type: Remote
Location: Remote • Pennsylvania • 🇺🇸 United States
Visit company websiteSalary
💰 $169,700 - $267,200 per year
Job Level
Lead
About the role
- Work within teams of highly collaborative, cross-functional scientists to contribute to the discovery and clinical development of therapeutics across various modalities
- Guide the design and interpretation of in silico, in vitro, and in vivo analyses to support the discovery of therapeutics with the desired DMPK profile
- Assess DDI risk using static mechanistic and/or physiologically based pharmacokinetic (PBPK) models and guide clinical development teams on DDI strategy
- Author source reports and documents in support of regulatory filings
- Independently evaluate and predict potential program risks, while implementing appropriate strategies to address liabilities to ensure efficient program progression and decision making
Requirements
- PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Pharmacokinetics, Pharmacodynamics, Chemistry, Biomedical Engineering, Biochemistry, Toxicology, Biology, or relevant STEM fields
- Master’s degree with 10+ years relevant experience or PhD with 7 + years of industry/applied drug discovery/development experience in a relevant field with a focus on discovery and development of therapeutics of various modalities (including small molecules, antibodies, and drug conjugates)
- Experienced in integrating preclinical DMPK and pharmacology to enable translational modeling and simulation to support dose selection, design of PK/PD and safety assessment studies, and dose justifications for preclinical and clinical studies
- Experience in assessing the impact of various factors on the pharmacokinetics and pharmacodynamics of novel therapeutics and communicating analyses and recommendations to interdisciplinary teams and management
- Experience with authoring documents in support of IB, IND, WMA filings, and responses to regulatory inquiries
- Demonstrated track record as an effective collaborator on multi-disciplinary discovery and development teams
- Strong leadership, interpersonal, communication, problem solving, and collaboration skills, while delivering results on firm deadlines.
Benefits
- medical, dental, vision healthcare and other insurance benefits (for employee and family)
- retirement benefits, including 401(k)
- paid holidays
- vacation
- compassionate and sick days
Applicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard skills
pharmacokineticspharmacodynamicsDMPKin silico analysisin vitro analysisin vivo analysisphysiologically based pharmacokinetic modelstranslational modelingdose selectionsafety assessment studies
Soft skills
leadershipinterpersonal skillscommunicationproblem solvingcollaborationeffective collaborationdecision makingresults deliverytime managementteamwork
Certifications
PhDMaster's degree
