Principal Software Engineer – Variant Knowledge Platform

Labcorp

Principal Software Engineer for Labcorp's Variant Knowledge Platform, focusing on variant identity, classification, and annotation. Leading technical designs and cross-team initiatives to drive health improvements.

Posted 6/26/2026full-timeRemote • North Carolina • 🇺🇸 United StatesLead💰 $180,000 - $205,000 per yearWebsite

Tech Stack

Tools & technologies

AWSCloudPython

About the role

Key responsibilities & impact

Own the technical design for large, ambiguous, open-ended problems that span the Variant Knowledge Platform and the broader interpretation stack
Define and evolve the data models for variant identity, classification, and annotation
Design production-grade, versioned REST API contracts
Lead the evolution of the systems that turn raw bioinformatic data into trustworthy variant- and sample-level information
Drive the architecture for automating evidence placement and classification
Define org-wide system architectures
Lead cross-team technical programs
Set the strategy for system operability
Lead large-scale data migration and backfill efforts
Mentor and level up engineers across multiple teams
Partner with cross-functional stakeholders to identify business opportunities

Requirements

What you’ll need

Bachelor's Degree
Five or more years of experience in REST API and contract design, including versioning and depreciation strategy and secure service-to-service authentication (e.g., Okta-based identity)
Two or more years of experience designing and operating cloud-based services on AWS
Five or more years of experience in a primary backend programming language used for data-intensive services (e.g., Python)

Benefits

Comp & perks

Medical
Dental
Vision
Life
STD/LTD
401(k)
Paid Time Off (PTO) or Flexible Time Off (FTO)
Tuition Reimbursement
Employee Stock Purchase Plan

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

REST API designdata modelingbioinformaticscloud-based servicesPythondata migrationevidence placementsystem architectureversioningsecure service-to-service authentication

Soft Skills

leadershipmentoringcross-team collaborationstrategic planningproblem-solving

Certifications

Bachelor's Degree