Senior Manager, Benefits, HRIS

Karyopharm Therapeutics Inc.

Senior Manager, Benefits & HRIS optimizing employee benefits and HRIS programs at Karyopharm Therapeutics developing differentiated therapies for patients with cancer.

Posted 5/28/2026full-timeRemote • 🇺🇸 United StatesSenior💰 $140,000 - $175,000 per yearWebsite

About the role

Key responsibilities & impact

Leads the strategy, administration, governance, and continuous improvement of Benefits, HRIS, and related HR operations in alignment with business objectives.
Oversees health and welfare, retirement, leave, disability, wellness, and voluntary benefits programs, including plan design, renewals, benchmarking, open enrollment, and employee communications.
Manages broker, carrier, retirement plan, COBRA, FSA/HSA, leave administration, HRIS, and other vendor relationships, including contracts, service levels, escalations, budgets, purchase orders, and compliance deliverables.
Ensures compliance with applicable benefits and employment requirements, including ERISA, ACA, COBRA, HIPAA, Section 125, FMLA, ADA, required filings, notices, plan documents, Forms 5500, ACA reporting, nondiscrimination testing, audits, SOPs, and documentation retention.
Provides guidance to employees and managers on benefits, leave administration, HR policies and procedures, HRIS, employee data, and HR operational best practices.
Oversees HRIS data integrity, reporting, employee records, workflows, system security, access controls, confidentiality protocols, and audit readiness.
Leads HRIS configuration, enhancements, integrations, testing, release management, and employee self-service tools to support scalable HR processes.
Develops HR metrics and uses AI-enabled tools, people analytics, and workforce data insights to improve operational efficiency, automate processes, support workforce planning, and enhance the employee experience.
Partners with Payroll, Finance, Accounting, IT, Legal, Quality, and external partners on benefits deductions, payroll integrations, budgeting, invoice reconciliation, accruals, cost analysis, and related operational needs.
Supports onboarding, offboarding, Inclusion & Wellness initiatives, and related employee communications through accurate eligibility administration, HRIS updates, planning, and execution.
Leads, coaches, and develops Benefits and HRIS team members while promoting collaboration, responsiveness, confidentiality, data accuracy, and continuous improvement.

Requirements

What you’ll need

Bachelor's degree in Human Resources, Business Administration, Finance, Information Systems, or related field
8+ years of HR experience, including 5+ years leading benefits, HRIS, or HR Operations programs
Strong knowledge of benefits administration and compliance, including ERISA, ACA, COBRA, HIPAA, FMLA, ADA, Section 125, and retirement plans
Experience leading open enrollment, plan renewals/design, vendor management, employee communications, and Benefits/HRIS projects
Proficiency with HRIS, benefits platforms, payroll integrations, reporting tools, Microsoft Office, and AI-enabled HR tools
Strong analytical, organizational, communication, and relationship-building skills with high attention to detail, confidentiality, and data accuracy
Ability to manage multiple priorities, budgets, vendors, process improvements, and cross-functional initiatives

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

benefits administrationHRIScompliancevendor managementdata integrityreportingemployee communicationsprocess improvementspeople analyticsworkforce planning

Soft Skills

analytical skillsorganizational skillscommunication skillsrelationship-building skillsattention to detailconfidentialitydata accuracyleadershipcoachingcollaboration

Certifications

Bachelor's degree in Human ResourcesBachelor's degree in Business AdministrationBachelor's degree in FinanceBachelor's degree in Information Systems