Senior Manager, People Operations

Karyopharm Therapeutics Inc.

Senior Manager of People Operations leading employee lifecycle processes in a biotechnology company. Overseeing HR operational programs and developing people strategy with focus on collaboration and compliance.

Posted 5/22/2026full-timeRemote • 🇺🇸 United StatesSeniorWebsite

About the role

Key responsibilities & impact

Leads and oversees the employee onboarding and offboarding experience in partnership with key stakeholders
Partners with HR leadership to develop and execute strategic People Operations initiatives aligned with business objectives
Oversees employee recognition and engagement programs to support a positive and inclusive company culture
Manages and enhances onboarding programs, including onboarding agendas and the new hire buddy program
Ensures compliance with employment eligibility verification requirements and oversees all I-9 documentation processes
Provides guidance to employees and managers regarding HR policies, procedures, and best practices
Collaborates cross-functionally with IT, Payroll, Facilities, Administration, Quality, Legal, and other teams to ensure operational effectiveness
Oversees HRIS data integrity, reporting, employee records management, onboarding and offboarding documentation, and audit readiness
Drives process improvement initiatives and implements scalable operational efficiencies across HR workflows and procedures
Manages vendor relationships related to background checks, immigration, employment verifications, HR systems, and other HR operational services
Partners with HR Centers of Excellence during key annual processes, including performance reviews, compensation planning, succession planning, and engagement surveys
Oversees legal contract coordination, budget tracking, and purchase order processing for the HR function
Assists and manages immigration processes for new and existing employee cases in partnership with external counsel and internal stakeholders
Partners with Compensation and Finance teams to support equity administration and organizational planning processes
Collaborates with HR leadership to execute strategic Human Resources initiatives and change management activities
Leads the review and maintenance process to ensure all job descriptions are accurate, compliant, and aligned with organizational structure
Facilitates new hire orientation sessions and supports leadership development and employee training initiatives
Oversees offboarding activities, including separation documentation, benefits communications, exit interviews, and risk mitigation activities
Partners with Payroll to ensure accurate and timely payroll-related documentation and processing
Supports Inclusion & Wellness initiatives and programs through strategic planning, communication, and execution
Leads HR compliance activities related to GxP training records, audit readiness, SOP management, and documentation retention requirements
Partners with Talent Acquisition and hiring managers to support workforce planning, hiring operations, and onboarding activities
Leverages AI-driven tools, HR analytics, and workforce data insights to enhance operational efficiency, support strategic decision-making, improve employee experience, and drive continuous process improvement across the HR function
Develops and analyzes HR metrics and reporting related to turnover, headcount, engagement, and operational performance
Leads the adoption and governance of AI-enabled HR technologies and people analytics to optimize workforce planning, operational effectiveness, and employee engagement strategies
Acts as a trusted advisor to managers and employees on employee relations matters, organizational changes, and HR operational practices
Ensures compliance with federal, state, and local employment laws, including leave administration, accommodations, and policy administration

Requirements

What you’ll need

Bachelor’s degree; Master’s degree or HR certification preferred
Minimum of 8 years of Human Resources experience, including at least 5 years in HR Operations or People Operations leadership roles
Experience leveraging AI tools and technologies to improve HR operations, reporting, employee experience, and process automation required
Experience within the biotechnology, pharmaceutical, healthcare, or other regulated industry strongly preferred
Strong interpersonal, conflict resolution, verbal, written, and presentation communication skills
Experience managing vendor relationships, budgets, and cross-functional projects
Excellent organizational skills with the ability to manage multiple priorities and projects simultaneously
Strong attention to detail and commitment to data accuracy, confidentiality, and compliance
Process improvement mindset with the ability to identify and implement operational efficiencies
Comprehensive knowledge of employment laws, HR compliance requirements, and HR best practices
Experience with HRIS systems and advanced proficiency in Microsoft Office applications preferred.

Benefits

Comp & perks

comprehensive benefits (medical, dental, vision, 401(k), and more)
equity
annual target bonuses

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

HR OperationsPeople OperationsHRISAI toolsHR analyticsprocess improvementemployment lawsdata accuracycompliancevendor management

Soft Skills

interpersonal skillsconflict resolutioncommunication skillsorganizational skillsattention to detailpresentation skillsproject managementstrategic planningemployee relationsleadership development

Certifications

Bachelor's degreeMaster's degreeHR certification