Senior Principal Scientist, Data Science RWE

Johnson & Johnson

Senior Principal Scientist overseeing RWE projects in Innovative Medicine at Johnson & Johnson. Driving scientific leadership and mentoring in data science for healthcare solutions.

Posted 7/17/2026full-timeTitusville • Massachusetts, New Jersey, Pennsylvania • 🇺🇸 United StatesSenior💰 $137,000 - $235,750 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in Real-World Evidence (RWE) methodologies, statistical analysis, and programming, with a strong focus on developing actionable insights from diverse data sources. Proven ability to lead projects, mentor teams, and create comprehensive study protocols and analysis plans.

Highest-signal resume keywords

Ph.D. In EpidemiologyExpert Coding Skills In RExpert Coding Skills In PythonExpert Coding Skills In SASExtensive Experience With RWE Studies

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Statistical AnalysisData ExtractionData CleaningStudy DesignProgramming ExpertiseBias Mitigation TechniquesAnalysis-Ready Data CreationStatistical Programming DeliverablesReal-World Data MethodologiesComparative Effectiveness Analysis

Soft Skills

LeadershipMentoringThought Leadership

Industry Keywords

Real-World EvidenceEHRInsurance ClaimsRegistry DataBiopharmaHealthcare IndustryClinical Trial Data Structure

Tech Stack

Tools & technologies

Python

About the role

Key responsibilities & impact

Be a hands-on scientific and technical leader, leading a portfolio of RWE projects, developing best practices, and mentoring team members.
Identify common technical requirements for RWE projects, develop and maintain a common suite of tools that enable RWE data scientists to accelerate project delivery.
End-to-end expertise in RWE studies including conceptualizing research questions, data feasibility, study design, analysis, programming, and interpretation.
Provide thought leadership and hands-on programming expertise for developing and applying Real-World Data (“RWD”) methodologies to mitigate observed and unobserved biases in the execution of external control arm studies, hybrid control studies, comparative effectiveness analyses, etc.
Provide thought leadership and hands-on programming expertise to generate actionable insights from post-hoc RCT analyses, observational databases, and literature reviews to support regulatory agency interactions.
Independently create study protocols, statistical analysis plans, and statistical programming deliverables including analysis-ready data, tables and figures
Partner with the Data Science Therapeutic Area scientists to conceptualize, lead, shape and deliver Real World Evidence

Requirements

What you’ll need

A Ph.D. degree in epidemiology or biostatistics
Expert coding skills using R, Python, or SAS
At least 5 years of relevant experience within biopharma companies, RWE consulting firms, or other relevant healthcare industries
Extensive hands-on experience with data extraction, cleaning, and analysis, as well as statistical methods to mitigate confounding and selection biases
Expertise with multiple real-world data sources (EHR, insurance claims, registry data).
Familiarity with clinical trial data structure

Benefits

Comp & perks

Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
This position is eligible to participate in the Company’s long-term incentive program.
Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:
Vacation –120 hours per calendar year
Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year
Holiday pay, including Floating Holidays –13 days per calendar year
Work, Personal and Family Time - up to 40 hours per calendar year
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
Caregiver Leave – 80 hours in a 52-week rolling period10 days
Volunteer Leave – 32 hours per calendar year
Military Spouse Time-Off – 80 hours per calendar year