Director, Protein Sciences

Johnson & Johnson

Director, Protein Sciences at Johnson & Johnson integrating target biology insights and computational protein design. Collaborating across biotech teams to develop medicines and pioneering drug concepts.

Posted 7/10/2026full-timeSpring House • Massachusetts, Pennsylvania • 🇺🇸 United StatesLead💰 $164,000 - $282,900 per yearWebsite

About the role

Key responsibilities & impact

Lead evaluation of therapeutic targets, including: Structural, sequence, and domain architecture analysis.
Integration of internal and external data (literature, databases, structural repositories).
Define antigen and engineered-cell design strategies to support antibody discovery: Construct design and domain selection, Epitope exposure and conformational state optimization, Strategies for difficult targets (e.g., multi-pass membrane proteins) including Nanodisc technology and nucleic acid immunogen design.
Apply computational and structural biology approaches to protein design: Homology modeling, structural analysis, and rational mutagenesis.
Integration of emerging AI/ML-based protein design tools.
Engineer proteins to improve: Stability and expression, Functional relevance for discovery assays and immunization.

Requirements

What you’ll need

A minimum of a Ph.D. in Biochemistry, Structural Biology, Protein Engineering, or a related discipline is required.
A minimum of 10 years of experience in biologics discovery or protein sciences is required.
Demonstrated leadership experience within the pharmaceutical or biotech industry is required.
Strong knowledge in the following is required: antigen design and generation for antibody discovery; structural biology and protein sequence analysis; biologics discovery workflows from target to lead identification.
Experience or domain knowledge in Oncology, Immunology, and/or Neuroscience is preferred.
People management experience is preferred.
Must have excellent verbal and written communication skills.
Must be strategic with a strong scientific mindset.
The ability to operate effectively within a highly coordinated, fast-paced matrix environment is required.

Benefits

Comp & perks

Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).
This position is eligible to participate in the Company’s long-term incentive program.
Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits: Vacation – 120 hours per calendar year.
Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado – 48 hours per calendar year; for employees who reside in the State of Washington – 56 hours per calendar year.
Holiday pay, including Floating Holidays – 13 days per calendar year.
Work, Personal and Family Time - up to 40 hours per calendar year.
Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child.
Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year.
Caregiver Leave – 80 hours in a 52-week rolling period.
10 days Volunteer Leave – 32 hours per calendar year.
Military Spouse Time-Off – 80 hours per calendar year.

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

Structural BiologyProtein Sequence AnalysisHomology ModelingRational MutagenesisNanodisc TechnologyNucleic Acid Immunogen DesignAI/ML-Based Protein Design Tools

Soft Skills

Excellent Verbal CommunicationExcellent Written CommunicationStrategic Thinking