
Principal Scientist, Spatial Omics
Johnson & Johnson
full-time
Posted on:
Location Type: Hybrid
Location: Cambridge • Massachusetts • Pennsylvania • United States
Visit company websiteExplore more
Salary
💰 $117,000 - $201,250 per year
Job Level
Tech Stack
About the role
- Leading the development, optimization, and validation of spatial genomics and molecular profiling assays to support neuroscience, oncology, and immunology programs.
- Designing and executing experimental workflows involving tissue processing, immunohistochemistry, in situ hybridization, microscopy, high-resolution slide imaging and sequencing.
- Establishing and refining new molecular assays, including troubleshooting, workflow development, and technical feasibility assessments.
- Building and scaling laboratory infrastructure, including lab setup, instrumentation planning, and operational readiness.
- Managing CROs and external partners, ensuring high-quality data generation, timeline alignment, and technical deliverables.
- Collaborating closely with therapeutic area teams to translate multiomics and spatial readouts into actionable biological insights.
- Contributing to data workflows by supporting early-stage data mapping, QC frameworks, and analytical handoffs to computational teams.
Requirements
- Minimum of a PhD in Genetics, Genomics, Molecular Biology, Molecular Pathology, Systems biology, Human biology or a related discipline is required.
- Post-doctoral fellowship in a related field is required.
- Minimum of 6 years of biotech or pharmaceutical industry experience is required.
- Academic staff scientist experience in deeply technical, matrixed, project-facing roles will be considered.
- Strong track record of high-impact scientific deliverables as evidenced by publications, presentations, and recognition within the scientific community.
- Deep, technical spatial omics expertise is required, including understanding of end-to-end workflows, methods limitations, and mitigation strategies.
- Excellent written communication, verbal communication, and oral presentation skills are required.
- Experience with Multiomic Datasets is required.
- Demonstrated ability to work across disciplines and functional areas is required.
- Ability to apply novel approaches to address complex biology questions, as evidenced through strong peer-reviewed publications is required.
- Proficiency in programming languages such as R or Python is preferred.
- In vitro cell culture and genomics library design experience is preferred.
Benefits
- medical
- dental
- vision
- life insurance
- short and long-term disability
- business accident insurance
- group legal insurance
- consolidated retirement plan (pension)
- savings plan (401(k))
- long-term incentive program
- vacation – 120 hours per calendar year
- sick time - 40 hours per calendar year; for employees in Colorado – 48 hours / Washington – 56 hours
- holiday pay, including Floating Holidays – 13 days per calendar year
- Work, Personal and Family Time - up to 40 hours per calendar year
- Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
- Bereavement Leave – 240 hours for an immediate family member; 40 hours for an extended family member per calendar year
- Caregiver Leave – 80 hours in a 52-week rolling period
- Volunteer Leave – 32 hours per calendar year
- Military Spouse Time-Off – 80 hours per calendar year
Applicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard Skills & Tools
spatial genomicsmolecular profiling assaysimmunohistochemistryin situ hybridizationmicroscopyhigh-resolution slide imagingsequencingdata mappingQC frameworksprogramming languages (R, Python)
Soft Skills
written communicationverbal communicationoral presentationcollaborationproblem-solvingcross-disciplinary teamworkproject managementtechnical troubleshootingworkflow developmentanalytical thinking
Certifications
PhD in GeneticsPhD in GenomicsPhD in Molecular BiologyPhD in Molecular PathologyPhD in Systems BiologyPhD in Human BiologyPost-doctoral fellowship