
Senior Principal Scientist, Spatial Omics
Johnson & Johnson
full-time
Posted on:
Location Type: Hybrid
Location: Cambridge • Massachusetts • Pennsylvania • United States
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Salary
💰 $137,000 - $235,750 per year
Job Level
About the role
- Develop and apply state-of-the-art AI/ML, statistical, and computational frameworks to analyze genomics, transcriptomics, proteomics, metabolomics, single-cell, and multi-omics datasets.
- Lead the design and execution of spatial omics analyses at massive scale, integrating imaging-based, sequencing-based, and multiplexed spatial platforms to uncover tissue architecture, cellular neighborhoods, and microenvironmental dynamics.
- Build scalable pipelines to preprocess, QC, harmonize, and integrate terabyte- to petabyte-scale spatial omics datasets, enabling discovery-ready data layers and advanced modeling.
- Deploy, adapt and develop agent-based models (ABM) to simulate cellular interactions, tissue-level organization, and dynamic biological processes, incorporating outputs from multimodal omics and spatial measurements.
- Fuse mechanistic models with ML/AI frameworks to generate hybrid predictive systems for target discovery, perturbation response, and disease progression modeling.
- Deploy and create novel ML architectures, including deep learning, generative models, graph neural networks, and causal inference frameworks that are tailored for biological complexity.
- Design and implement scalable algorithms for high-dimensional, multimodal integration of spatial, molecular, and phenotypic data.
- Map, influence, and guide the development of computational and data architecture needed to support next-generation omics and ML workloads.
Requirements
- Minimum of a Ph.D. in Computational Biology, Bioinformatics, Computer Science, Statistical Genetics, Systems Biology, Applied Mathematics/Physics, or a related quantitative discipline.
- Minimum of 9 years of post-doctoral, industry or academic experience applying advanced computational, statistical, and machine-learning methods to biological problems.
- Deep expertise across multiple omics modalities, including genomics, transcriptomics, proteomics, metabolomics, and spatial omics (e.g., spatial transcriptomics, multiplexed imaging, spatial proteomics).
- Demonstrated ability to analyze, integrate, and interpret very large-scale, multimodal datasets (multi-TB to PB scale), including the design of scalable pipelines and distributed computation strategies.
- Expert-level proficiency in modern ML/AI frameworks, such as PyTorch, TensorFlow, JAX, scikit-learn, and deep-learning architectures relevant to biological modeling.
- Strong background in agent-based modeling, systems biology modeling, or hybrid mechanistic-ML modeling frameworks.
- Proven ability to design and influence data and computational architectures, including experience working with cloud-native analytical ecosystems (Azure, AWS, or GCP) and large-scale data engineering workflows.
- Demonstrated scientific leadership as an individual contributor, including the ability to independently drive complex research programs, set technical direction, and influence cross-functional strategy.
- A strong publication record in high-impact journals or top-tier ML/AI conferences, reflecting innovation in computational biology or applied machine learning.
- Proficiency in Python and experience with scientific computing libraries (NumPy, SciPy, pandas) and workflow orchestration tools.
Benefits
- medical insurance
- dental insurance
- vision insurance
- life insurance
- short and long-term disability
- business accident insurance
- group legal insurance
- retirement plan (pension)
- savings plan (401(k))
- annual performance bonus
- parental leave
- vacation time
- sick time
- holiday pay
- volunteer leave
- caregiver leave
- military spouse time-off
Applicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard Skills & Tools
AI/ML frameworkscomputational frameworksstatistical methodsagent-based modelingdeep learninggenerative modelsgraph neural networkscausal inference frameworkshigh-dimensional data integrationdata architecture design
Soft Skills
scientific leadershipindependent researchtechnical directioncross-functional influence