Johnson & Johnson

Senior Principal Scientist, Spatial Omics

Johnson & Johnson

full-time

Posted on:

Location Type: Hybrid

Location: CambridgeMassachusettsPennsylvaniaUnited States

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Salary

💰 $137,000 - $235,750 per year

Job Level

About the role

  • Develop and apply state-of-the-art AI/ML, statistical, and computational frameworks to analyze genomics, transcriptomics, proteomics, metabolomics, single-cell, and multi-omics datasets.
  • Lead the design and execution of spatial omics analyses at massive scale, integrating imaging-based, sequencing-based, and multiplexed spatial platforms to uncover tissue architecture, cellular neighborhoods, and microenvironmental dynamics.
  • Build scalable pipelines to preprocess, QC, harmonize, and integrate terabyte- to petabyte-scale spatial omics datasets, enabling discovery-ready data layers and advanced modeling.
  • Deploy, adapt and develop agent-based models (ABM) to simulate cellular interactions, tissue-level organization, and dynamic biological processes, incorporating outputs from multimodal omics and spatial measurements.
  • Fuse mechanistic models with ML/AI frameworks to generate hybrid predictive systems for target discovery, perturbation response, and disease progression modeling.
  • Deploy and create novel ML architectures, including deep learning, generative models, graph neural networks, and causal inference frameworks that are tailored for biological complexity.
  • Design and implement scalable algorithms for high-dimensional, multimodal integration of spatial, molecular, and phenotypic data.
  • Map, influence, and guide the development of computational and data architecture needed to support next-generation omics and ML workloads.

Requirements

  • Minimum of a Ph.D. in Computational Biology, Bioinformatics, Computer Science, Statistical Genetics, Systems Biology, Applied Mathematics/Physics, or a related quantitative discipline.
  • Minimum of 9 years of post-doctoral, industry or academic experience applying advanced computational, statistical, and machine-learning methods to biological problems.
  • Deep expertise across multiple omics modalities, including genomics, transcriptomics, proteomics, metabolomics, and spatial omics (e.g., spatial transcriptomics, multiplexed imaging, spatial proteomics).
  • Demonstrated ability to analyze, integrate, and interpret very large-scale, multimodal datasets (multi-TB to PB scale), including the design of scalable pipelines and distributed computation strategies.
  • Expert-level proficiency in modern ML/AI frameworks, such as PyTorch, TensorFlow, JAX, scikit-learn, and deep-learning architectures relevant to biological modeling.
  • Strong background in agent-based modeling, systems biology modeling, or hybrid mechanistic-ML modeling frameworks.
  • Proven ability to design and influence data and computational architectures, including experience working with cloud-native analytical ecosystems (Azure, AWS, or GCP) and large-scale data engineering workflows.
  • Demonstrated scientific leadership as an individual contributor, including the ability to independently drive complex research programs, set technical direction, and influence cross-functional strategy.
  • A strong publication record in high-impact journals or top-tier ML/AI conferences, reflecting innovation in computational biology or applied machine learning.
  • Proficiency in Python and experience with scientific computing libraries (NumPy, SciPy, pandas) and workflow orchestration tools.
Benefits
  • medical insurance
  • dental insurance
  • vision insurance
  • life insurance
  • short and long-term disability
  • business accident insurance
  • group legal insurance
  • retirement plan (pension)
  • savings plan (401(k))
  • annual performance bonus
  • parental leave
  • vacation time
  • sick time
  • holiday pay
  • volunteer leave
  • caregiver leave
  • military spouse time-off
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
AI/ML frameworkscomputational frameworksstatistical methodsagent-based modelingdeep learninggenerative modelsgraph neural networkscausal inference frameworkshigh-dimensional data integrationdata architecture design
Soft Skills
scientific leadershipindependent researchtechnical directioncross-functional influence