
Principal Scientist, Spatial Omics
Johnson & Johnson
full-time
Posted on:
Location Type: Office
Location: Cambridge • Massachusetts • Pennsylvania • United States
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Salary
💰 $117,000 - $201,250 per year
Job Level
Tech Stack
About the role
- Leading the development, optimization, and validation of spatial genomics and molecular profiling assays to support neuroscience, oncology, and immunology programs.
- Designing and executing experimental workflows involving tissue processing, immunohistochemistry, in situ hybridization, microscopy, high‑resolution slide imaging and sequencing.
- Establishing and refining new molecular assays, including troubleshooting, workflow development, and technical feasibility assessments.
- Building and scaling laboratory infrastructure, including lab setup, instrumentation planning, and operational readiness.
- Managing CROs and external partners, ensuring high‑quality data generation, timeline alignment, and technical deliverables.
- Collaborating closely with therapeutic area teams to translate multiomics and spatial readouts into actionable biological insights.
- Contributing to data workflows by supporting early-stage data mapping, QC frameworks, and analytical handoffs to computational teams.
Requirements
- Minimum of a PhD in Genetics, Genomics, Molecular Biology, Molecular Pathology, Systems biology, Human biology or a related discipline is required.
- Post-doctoral fellowship in a related field is required.
- A minimum of 6 years of biotech or pharmaceutical industry experience is required.
- Strong track record of high-impact scientific deliverables as evidenced by publications, presentations, and recognition within the scientific community.
- Deep, technical spatial omics expertise is required, including understanding of end-to-end workflows, methods limitations, and mitigation strategies.
- Excellent written communication, verbal communication, and oral presentation skills are required.
- Experience with Multiomic Datasets is required.
- Demonstrated ability to work across disciplines and functional areas is required.
- Ability to apply novel approaches to address complex biology questions, as evidenced through strong peer-reviewed publications is required.
- Proficiency in programming languages such as R or Python is preferred.
- In vitro cell culture and genomics library design experience is preferred.
- Experience as a problem solver, and team collaborator able to facilitate understanding between biologists and data scientists is preferred.
- Ability to manage multiple projects and meet deadlines is preferred.
- Experience working with and/or guiding external collaborators in industry or academia is preferred.
Benefits
- medical insurance
- dental insurance
- vision insurance
- life insurance
- short and long-term disability
- business accident insurance
- group legal insurance
- consolidated retirement plan (pension)
- savings plan (401(k))
- long-term incentive program
- Vacation –120 hours per calendar year
- Sick time - 40 hours per calendar year
- Holiday pay, including Floating Holidays –13 days per calendar year
- Work, Personal and Family Time - up to 40 hours per calendar year
- Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child
- Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year
- Caregiver Leave – 80 hours in a 52-week rolling period
- Volunteer Leave – 32 hours per calendar year
- Military Spouse Time-Off – 80 hours per calendar year
Applicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard Skills & Tools
spatial genomicsmolecular profiling assaysimmunohistochemistryin situ hybridizationmicroscopyhigh-resolution slide imagingsequencingmultiomic datasetsprogramming languages (R, Python)genomics library design
Soft Skills
written communicationverbal communicationoral presentationproblem solvingteam collaborationproject managementcross-disciplinary collaborationability to meet deadlinestechnical feasibility assessmenttroubleshooting
Certifications
PhD in GeneticsPhD in GenomicsPhD in Molecular BiologyPhD in Molecular PathologyPhD in Systems BiologyPhD in Human BiologyPost-doctoral fellowship