Principal AI Systems Engineer

Iovance Biotherapeutics, Inc.

Principal AI Systems Engineer at Iovance Biotherapeutics focusing on AI system design and deployment. Responsible for delivering innovative AI solutions to support tumor therapy development.

Posted 6/1/2026full-timeRemote • 🇺🇸 United StatesLead💰 $175,000 - $200,000 per yearWebsite

Tech Stack

Tools & technologies

AWS

About the role

Key responsibilities & impact

Design, build, and ship AI systems against the approved Iovance AI roadmap
Implement production-grade Retrieval-Augmented Generation (RAG) systems
Build, maintain, and run evaluation harnesses for AI systems
Design and implement integrations between AI systems and Iovance enterprise systems
Own and maintain LLM security controls for production AI systems
Design, develop, deploy, and maintain AI agents
Establish and uphold modern engineering practices for AI development
Conduct hands-on technical evaluation of AI vendors, tools, and Foundation Models
Implement and operate technical controls for production AI systems
Author technical documentation appropriate to the system risk tier
Mentor junior engineers who collaborate on AI projects

Requirements

What you’ll need

10+ years of progressive software and/or AI/ML engineering experience
Deep, hands-on production experience with Retrieval-Augmented Generation (RAG)
Practical working experience across multiple frontier model families
Strong software engineering fundamentals
Hands-on, builder disposition
Working production experience with AWS data and AI services is strongly preferred
Working knowledge of enterprise search and retrieval services

Benefits

Comp & perks

Health insurance
Flexible work hours
Professional development opportunities

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

AI systems designRetrieval-Augmented Generation (RAG)AI agents developmentLLM security controlstechnical evaluation of AI vendorstechnical documentationsoftware engineering fundamentalsenterprise searchAWS data servicesAWS AI services

Soft Skills

mentoringcollaborationhands-on disposition