Senior Clinical Research Associate

ICON plc

Perform site management and monitoring activities for Oncology clinical trials at ICON plc. Ensure data integrity and subject safety while maintaining inspection readiness across clinical investigative sites.

Posted 5/13/2026full-timeRemote • California • 🇺🇸 United StatesSenior💰 $110,520 - $138,150 per yearWebsite

About the role

Key responsibilities & impact

Perform site management activities to support the client's Oncology site success and maintain a continuous state of inspection readiness
Act as the primary contact and facilitate efficient communications between the client's clinical trial team and the sites
Perform remote and on-site monitoring/co-monitoring visits (Site Qualification Visits, Site Initiation Visits, Interim Monitoring Visits and Close-Out Visits) to ensure data integrity and subject safety in the client's trials
May perform oversight activities to assess monitoring quality and train/mentor less experienced CRAs
Promptly document monitoring activities and submit/approve visit reports
Manage site essential document collection and TMF reconciliation with site files
Support sites with local Institutional Review Board (IRB)/Ethics Committee (EC) submissions and confirm approvals
Regularly review site Key Risk Indicator (KRI) metrics, issues and action items to detect trends and ensure prompt resolution
Independently determine root causes and develop/implement site Corrective Action and Preventive Action (CAPA) plans
Deliver training to ensure sites comply with the protocol, Standard Operating Procedures (SOPs), Good Clinical Practices (GCPs) and regulations
Support sites and the client's regulatory inspections
Contribute to site identification; drive site feasibility and qualification progress; and support site activation activities
Lead site engagement initiatives and foster relationships with key Oncology sites and networks

Requirements

What you’ll need

Bachelor’s degree (scientific field preferred)
5+ years monitoring clinical trials independently conducting on-site and remote monitoring visits.
At least 2 years monitoring solid tumor clinical trials.
1+ years early development trial experience
Solid tumor clinical trial experience is required
Experience utilizing Veeva systems is highly preferred
Demonstrated experience developing/maintaining site relationships and securing compliance
Expertise in GxPs and Oncology monitoring techniques (including Risk-Based Monitoring) and terminology
Experience collaborating with sites from initial engagement through close-out phases
Experience activating sites
Experience training site staff
Experience supporting sites and/or sponsors in regulatory inspections
Experience working within a Functional Services (or in-house) monitoring model is preferred
Willing to travel up to 50%

Benefits

Comp & perks

Various annual leave entitlements
A range of health insurance offerings to suit you and your family’s needs.
Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.
Global Employee Assistance Programme, TELUS Health, offering 24-hour access to a global network of over 80,000 independent specialised professionals who are there to support you and your family’s well-being.
Life assurance
Flexible country-specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidised travel passes, health assessments, among others.

ATS Keywords

✓ Tailor your resume

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools

clinical trial monitoringsite managementdata integritymonitoring quality assessmenttraining and mentoringTMF reconciliationKRI metrics analysisCAPA development and implementationprotocol complianceRisk-Based Monitoring

Soft Skills

communicationrelationship buildingproblem-solvingleadershiporganizational skillstraining deliveryindependencecollaborationattention to detailadaptability