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Iambic Therapeutics

Principal Engineer, Cloud Ops

Iambic Therapeutics

. Support and contribute to the Cloud Ops roadmap, aligning infrastructure initiatives with business priorities.

Posted 5/21/2026full-timeBoston • Massachusetts • 🇺🇸 United StatesLeadWebsite

Tech Stack

Tools & technologies
AnsibleAWSCloudDistributed SystemsDNSDockerKubernetesPackerTCP/IPTerraform

About the role

Key responsibilities & impact
  • Support and contribute to the Cloud Ops roadmap, aligning infrastructure initiatives with business priorities.
  • Provide technical leadership and drive architecture decisions across platform and infrastructure teams.
  • Lead the design and evolution of scalable, highly available AWS cloud infrastructure.
  • Build and operate production systems with a strong focus on reliability, performance, and cost efficiency.
  • Design and manage cloud networking (VPN, VPC, routing, DNS, load balancing, secure connectivity).
  • Implement Infrastructure as Code (Terraform) and automate provisioning and operations.
  • Troubleshoot complex issues across distributed systems, including networking and performance bottlenecks.
  • Apply security best practices and support the ISO 27001 compliance frameworks.
  • Improve observability, CI/CD pipelines, and overall operational maturity.
  • Mentor engineers in Cloud Services and influence Cloud Ops best practices across the org.

Requirements

What you’ll need
  • Minimum of 12 years of related experience with a bachelor’s degree; or 10 years and a master’s degree; or equivalent experience.
  • Strong understanding of CI/CD pipelines.
  • Strong Infrastructure as Code skills – for example in Docker, Packer/Ansible and Terraform/Terragrunt.
  • Strong understanding of AWS services and underlying technologies such as AWS IAM service and managing Kubernetes as a service (AWS EKS) including managing zero-downtime upgrades and debugging issues with deployments, controllers, etc. Deployed in the cluster.
  • Strong understanding of computer networks:
  • TCP/IP protocols.
  • IP block allocation across an organization.
  • Routing and VPN protocols.
  • AWS networking: VPCs, Transit Gateways, Customer Gateways, VPNs, flow logs, security groups, NACLs, etc.
  • Cloudflare networking experience.
  • Understanding of issues facing ML deployments including model training and inference challenges.
  • Ability to communicate with a variety of teams including IT, Computational Scientists, Software Developers, Cloud Ops and ML engineers

Benefits

Comp & perks
  • We offer industry leading competitive pay
  • company paid healthcare
  • flexible spending accounts
  • voluntary life insurance
  • 401K matching
  • uncapped vacation
  • onsite gym
  • dining

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools
AWSInfrastructure as CodeTerraformDockerAnsibleKubernetesCI/CD pipelinesTCP/IPcloud networkingISO 27001
Soft Skills
technical leadershipmentoringcommunication