Senior Clinical Trial Manager, Clinical Operations

Iambic Therapeutics

. Provide end-to-end operational leadership for complex clinical trials from start-up through close-out, ensuring delivery on time, within budget, and in compliance with global regulations and company SOPs .

Posted 4/21/2026full-timeRemote • California • 🇺🇸 United StatesSenior💰 $152,000 - $190,000 per yearWebsite

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Provide end-to-end operational leadership for complex clinical trials from start-up through close-out, ensuring delivery on time, within budget, and in compliance with global regulations and company SOPs
Lead cross-functional study teams and drive alignment across Clinical Development, Regulatory, Biometrics, and external partners
Develop and execute enrollment, site management, and monitoring strategies to ensure high-quality trial conduct and performance
Oversee CRO and vendor performance, including KPI management, monitoring quality oversight, document review and approval, and vendor selection support
Partner with Data Management and Medical to conduct ongoing data review and ensure timely query resolution
Develop and manage key study documents and operational tools, including protocols, informed consent forms, project plans, budgets, and study materials.
Lead study-related training for investigators, site personnel, and internal teams.
Proactively identify, assess, and escalate operational risks with mitigation strategies and clear recommendations.
Mentor and support junior clinical operations staff, including potential dotted-line management responsibilities.
Travel up to 10% as required to support study oversight and site engagement

Requirements

What you’ll need

Bachelor’s degree in life sciences or related field with 7+ years of progressive clinical trial management experience in biotech, pharmaceutical, and/or CRO environments
Demonstrated expertise managing clinical trials from start-up through close-out, with experience overseeing global, multi-site studies and CRO partners
Experience in oncology clinical trials required; solid tumor and early-phase (Phase I/Ib or II) experience preferred
In-depth knowledge of ICH-GCP, FDA/EMA regulations, and global regulatory requirements, with a strong focus on quality and inspection readiness
Proficiency with clinical trial systems, including CTMS, eTMF platforms, IRT systems, EDC systems, and safety databases
Ability to thrive in a collaborative, fast-paced, growth-stage biotech environment with evolving priorities and high accountability.

Benefits

Comp & perks

company paid healthcare
flexible spending accounts
voluntary life insurance
401K matching
uncapped vacation

ATS Keywords

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Hard Skills & Tools

clinical trial managementenrollment strategiessite managementmonitoring strategiesKPI managementdata reviewrisk assessmentoperational leadershipprotocol developmentbudget management

Soft Skills

leadershipcollaborationmentoringcommunicationproblem-solvingorganizational skillsadaptabilityteam alignmenttrainingstakeholder engagement