Staff HPC Infrastructure Engineer

Guardant Health

Staff HPC Infrastructure Engineer scaling genomics data storage, compute clusters, and networking at precision oncology company Guardant Health. Supporting on-premise and cloud infrastructure.

Posted 8/26/2026full-timeCalifornia • 🇺🇸 United StatesLead💰 $155,700 - $214,150 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in managing HPC clusters, integrating cloud solutions, and optimizing system performance. Proficient in Linux/Unix administration, high-performance networking, and automation tools, with a strong focus on documentation and mentoring.

Highest-signal resume keywords

HPC Cluster ManagementLinux/Unix AdministrationHigh-Performance NetworkingAutomation Tools (Ansible)Cloud Infrastructure (AWS, GCP, Azure)

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

HPC Solutions DevelopmentSystem AdministrationTCP/IP NetworkingData Storage ManagementPerformance TuningShell ScriptingPython ProgrammingTechnical DocumentationTroubleshootingCloud Bursting

Soft Skills

MentoringCollaborationCuriositySound Judgment

Tools & Technologies

XDMoDInfiniBandRoCERDMADockerKubernetesSlurmWarewulfRed Hat LinuxGPFS

Certifications & Qualifications

Cisco Certified Network Professional (CCNP)

Industry Keywords

High-Performance Computing (HPC)Cloud InfrastructureCompliance (HIPAA, SOX)Infrastructure EngineeringAutomation Processes

Tech Stack

Tools & technologies

AnsibleAWSAzureCloudDockerGoogle Cloud PlatformKubernetesLinuxPythonTCP/IPUnix

About the role

Key responsibilities & impact

Manage multiple HPC clusters and cluster file systems
Integrate cloud bursting into HPC abstraction work
Research, develop, and implement next-generation HPC solutions
Troubleshoot the production system stack down to source-code level, including shell scripts and Python
Maintain, monitor, and support infrastructure environments and facilities
Improve production monitoring capabilities
Support system reliability and performance improvements
Support medium- to high-complexity systems and applications with concurrent users, ensuring control, integrity, and accessibility
Support systems at remote locations, including internationally
Mentor junior engineers on HPC best practices
Collaborate with offsite consultants and vendors to maintain, troubleshoot, upgrade, and repair systems
Represent HPC networking and storage-integration topics in cross-functional planning with networking, SQA, DevOps/SRE, and the MSP
Set up and own XDMoD instances for HPC metrics and monitoring
Participate in a 24/7 on-call rotation
Act as technical peer for HPC networking and interconnect initiatives
Collaborate on HPC Ethernet design, performance tuning, and troubleshooting
Integrate HPC systems with enterprise bandwidth-on-demand connectivity across sites and cloud infrastructure
Manage and optimize connectivity to and from HPC systems and global locations
Partner with the storage engineer and MSP on HPC storage architecture and integration
Serve as technical point of contact for the MSP storage relationship, helping define SLAs, validate delivery, and escalate technical issues
Support transition of day-to-day storage operations to the MSP while maintaining performance and reliability

Requirements

What you’ll need

Bachelor’s degree in Computer Science or a related field with 8–12 years of relevant experience; Master’s degree with 6–8 years of relevant experience; or PhD with 3–5 years of relevant experience
Strong experience in systems and/or infrastructure engineering, including Linux/Unix administration and TCP/IP networking
Hands-on experience with automation tools, such as Ansible or equivalent technologies
Experience with high-performance networking technologies, such as InfiniBand, RoCE, RDMA, or equivalent, including troubleshooting in production environments
Experience supporting large-scale data storage and high-performance computing (HPC)/compute environments
Experience working with both on-premise and cloud-based infrastructure, such as AWS, Google Cloud Platform (GCP), Azure, or similar environments
Experience developing and supporting software release, operations, and infrastructure automation processes and toolsets
Strong experience creating and maintaining system administration and technical documentation
Ability to participate in a 24/7 on-call rotation
Background screening including criminal history required
Preferred: Cisco Certified Network Professional (CCNP) certification
Preferred: Experience with Arista networking, GPFS, Slurm, Warewulf, Red Hat Linux, cloud bursting, wide area file systems, Docker, Apptainer, Kubernetes, and HIPAA/SOX-compliant infrastructure
Demonstrated curiosity, sound judgment, and ability to critically evaluate and responsibly leverage AI-enabled tools according to company policies, ethical standards, and regulatory requirements

Benefits

Comp & perks

Hybrid work model with defined in-person/onsite collaboration days and work-from-home days for individual-focused time
Flexible work-life balance
Reasonable accommodations during hiring processes
Confidential handling of applicant information
Equal Opportunity Employer