Senior Lab and Medical Director, Computational Pathology

Guardant Health

Senior medical director leading computational pathology product development and laboratory oversight at Guardant Health, a precision oncology diagnostics company. Driving validation, regulatory readiness, clinical signout, and high-complexity testing quality.

Posted 8/5/2026full-timeCalifornia • 🇺🇸 United StatesSenior💰 $233,700 - $321,350 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in clinical leadership and oversight of Anatomic and Molecular Pathology laboratory operations, with a strong focus on computational pathology service development and regulatory compliance. Proven ability to contribute to product development, validation studies, and peer-reviewed publications in the field.

Highest-signal resume keywords

Doctor Of Medicine Or Doctor Of OsteopathyCertification In Anatomic Or Clinical PathologyExperience With Whole-Slide Imaging PlatformsRegulatory Submissions ExperienceNext-Generation Sequencing Familiarity

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Clinical OversightDiagnostic InterpretationComputational Pathology DevelopmentQuality ControlRegulatory ComplianceAI/ML Algorithm ValidationLaboratory ManagementImage Analysis SoftwareProficiency TestingStandard Operating Procedures Review

Soft Skills

CuriositySound JudgmentCritical EvaluationDelegationCommunication

Tools & Technologies

Whole-Slide Imaging PlatformsImage Analysis SoftwareAI-Enabled ToolsLaboratory Information SystemsValidation Study Design

Certifications & Qualifications

Doctor Of Medicine LicenseDoctor Of Osteopathy LicenseAmerican Board Of Pathology CertificationAmerican Osteopathic Board Of Pathology Certification

Industry Keywords

Computational PathologyAnatomic PathologyMolecular PathologyLiquid Biopsy TestingOncologyDiagnosticsBiotechDigital Health42 CFR 493.1443College Of American Pathologists Checklist

About the role

Key responsibilities & impact

Provide clinical leadership for delivery of computational pathology laboratory services and products
Provide clinical oversight of Anatomic Pathology and Molecular Pathology laboratory operations
Provide clinical signout and final diagnostic interpretation for molecular and/or anatomic pathology cases
Define internal strategy for computational pathology service development
Co-lead computational pathology product development with Technology and Product Development teams
Provide clinical input on use cases, annotation strategy, validation study design, regulatory submissions, software workflows, and launch readiness
Contribute to manuscripts and conference posters for computational pathology products
Explore partnerships expanding computational and molecular pathology services
Ensure testing systems provide quality services across pre-analytic, analytic, and post-analytic phases
Act as temporary Laboratory Director in the Laboratory Director's absence
Delegate technical, supervisory, clinical consultation, and testing responsibilities to qualified employees
Perform administrative duties for laboratory leadership and testing personnel
Ensure laboratory duties, onsite supervision, quality control, proficiency testing, personnel competency, safety, procedures, and regulatory requirements are fulfilled
Review standard operating procedures biennially and oversee corrective actions for unacceptable performance
Travel approximately 15% and adjust hours based on operational needs

Requirements

What you’ll need

Must be a Doctor of Medicine or Doctor of Osteopathy licensed to practice medicine or osteopathy in California; OR meet an alternative listed laboratory-director qualification
Certification in Anatomic or Clinical Pathology by the American Board of Pathology or American Osteopathic Board of Pathology, or equivalent qualifications; OR at least one year of laboratory training during medical residency; OR at least two years directing or supervising high-complexity testing; OR prior industry experience at a diagnostics, biotech, or digital health company
Experience with whole-slide imaging platforms, image analysis software, or validation of AI/ML-based algorithms
Track record of peer-reviewed publications or conference presentations in pathology, oncology, or computational pathology
Experience contributing to regulatory submissions, including 510(k), PMA, or LDT validation packages
Familiarity with next-generation sequencing and liquid biopsy testing
Earned doctoral degree in chemical, physical, biological, or clinical laboratory science from an accredited institution and certification by an HHS-approved board, or satisfy the stated grandfathered laboratory-director qualifications
Must fulfill requirements stated in 42 CFR 493.1443
Must fulfill requirements stated in the College of American Pathologists Checklist
Demonstrated curiosity, sound judgment, and ability to critically evaluate and responsibly use AI-enabled tools under company policies, ethical standards, and regulatory requirements
Background screening including criminal history is required
Ability to travel approximately 15%
Ability to work varying hours and days based on operational needs
Ability to sit or stand for extended periods and work around laboratory hazards, blood specimens, fumes, noise, and biohazard materials

Benefits

Comp & perks

Hybrid work model with defined in-person collaboration days and work-from-home days
Flexible work-life balance
Reasonable accommodations in hiring processes
Equal Opportunity Employer
Potential bonus, commission, or equity, if applicable
Company culture, core values, company meetings, sustainability commitment, recognition programs, and talent community opportunities