Director, Oncology Clinical Pharmacology Modeling and Simulation

GSK

Director of Oncology Clinical Pharmacology delivering modeling and simulation excellence in R&D. Leveraging expertise to inform the development of innovative oncology therapies.

Posted 5/2/2026full-timeUpper Providence • Massachusetts, North Carolina, Pennsylvania • 🇺🇸 United StatesLead💰 $188,100 - $313,500 per yearWebsite

About the role

Key responsibilities & impact

Defining and executing model-based development strategies for oncology projects
Planning, conducting and reporting exposure-response analysis, simulation-based trial design and dose selection, and population PK modelling
Applying innovative methods such as drug-disease modeling, longitudinal exposure-response analysis, model-based meta-analysis, quantitative systems pharmacology and AI/ML informed analyses to enhance data use and trial efficiency
Presenting strategy and defending outcome of model-based approaches to internal governance boards and regulatory agencies
Contributing to clinical program design, trial protocols, analysis plans, study reports and regulatory submissions
Write or review clinical pharmacology components of regulatory documents and responses
Implement best practices, trends, lessons learned from internal and external sources

Requirements

What you’ll need

PhD in Quantitative Clinical Pharmacology and Pharmacometrics disciplines (e.g., pharmacology, engineering or statistics)
5+ years of utilizing skills in mechanistic PKPD and longitudinal disease modelling
Verifiable proficiency in pharmacometric tools NONMEM or R
3+ years of experience in planning, performing, and reporting model-based analysis of clinical data per industry and regulatory standards
Strong drive and learning agility to build knowledge on a drug-disease system, symptom progression, standard of care, and trial design
Ability to keep up-to-date with and propose the implementation of new modeling approaches to inform drug development
Excellent interpersonal skills with strong oral/written communication and presentation skills.

Benefits

Comp & perks

Health care and other insurance benefits (for employee and family)
Retirement benefits
Paid holidays
Vacation
Paid caregiver/parental and medical leave

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

model-based developmentexposure-response analysissimulation-based trial designdose selectionpopulation PK modellingdrug-disease modelinglongitudinal exposure-response analysismodel-based meta-analysisquantitative systems pharmacologyAI/ML informed analyses

Soft Skills

interpersonal skillsoral communicationwritten communicationpresentation skillslearning agilitystrategic thinking

Certifications

PhD in Quantitative Clinical PharmacologyPhD in Pharmacometrics