Senior Principal Clinical Research Scientist

GRAIL

full-time

Posted on: 9/5/2025

Origin: • 🇺🇸 United States • California

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💰 $211,000 - $281,000 per year

Senior

Google Cloud Platform

About the role

Conceptualization, design, implementation and analysis of clinical evidence generation studies
Lead cross-functional teams on design, conduct and analysis of clinical studies with academic, community, and industry partners
Design and implement approaches to review, clean, analyze and integrate large and complex clinical datasets
Lead regular and ad-hoc data reviews and interpretation of clinical data; prepare and present summaries/documentations
Oversee data quality review activities and resolve data quality issues
Lead strategic efforts to advance clinical development and scientific plans; engage key opinion leaders; provide expert scientific input
Contribute to development of data collection forms and data/metadata standards
Collaborate with Biostatistics to develop statistical analysis plans and co-author clinical study reports
Represent Clinical Science as thought leader on cross-functional teams
Ensure data integrity and quality, appropriate blinding and data privacy standards
Develop electronic case report forms and other clinical data capture methods
Lead development of study reports, presentations, and publications
Conduct literature reviews and obtain external data (e.g., SEER, US Census) to inform or interpret study results
Develop formal networks with external investigators and thought leaders
Ensure compliance with industry regulations, policies, guidelines and standards

Advanced clinical/scientific degree (e.g. PharmD, PhD, MSN, MPH)
at least 5 years of oncology clinical and/or population science research experience (with advanced degree)
Minimum 10 years of experience working in industry
deep experience in cancer epidemiology, especially screening and early detection
Extensive experience with SEER or other population-based cancer registry data
Significant experience in designing and conducting clinical and/or real-world evidence studies, particularly registrational and/or clinical utility studies for reimbursement
Extensive experience in scientific communication with substantial peer-reviewed publications
Strong track record in data management and integrating complex, large-scale datasets
Knowledge of regulatory requirements (e.g. ICH, GCP, HIPAA)
Demonstrated ability to initiate and maintain effective relationships with internal and external collaborators
Demonstrated ability to lead cross-functional teams
Excellent interpersonal communication (written and verbal), presentation and organizational skills
Excellent team player with demonstrated track record of success in a fast-pace cross-functional team environment
Consistent commitment to delivering on team goals with a sense of shared purpose