Manager, Genetic Quality Assurance, Product Quality – Variant Interpretation, Genomics
Genomenon, Inc
full-time
Posted on:
Location Type: Remote
Location: United States
Visit company websiteExplore more
About the role
- Serve as the final scientific authority for complex or ambiguous variant interpretation cases, including conflicting clinical and functional evidence
- Apply deep expertise in ACMG/AMP guidelines to ensure accurate and defensible classifications
- Leverage clinical experience to contextualize variant interpretations and ensure clinical relevance and applicability
- Guide evaluation of functional studies and literature to support high-confidence interpretation decisions
- Support high-impact client deliverables, including clinical and pharmaceutical use cases
- Own QA/QC standards across all variant interpretation workflows
- Ensure consistent application of internal frameworks, nomenclature standards (HGVS), and interpretation criteria
- Oversee external data quality, including ClinVar submissions and discrepancy resolution
- Manage, mentor, and develop a team of QA scientists and curators
- Provide coaching on interpretation, evidence evaluation, and best practices
- Set clear performance expectations and maintain accountability for quality standards
- Design, implement, and continuously improve SOPs, QA processes, and workflows
- Identify systemic quality issues and lead solutions that scale across teams and projects
- Balance standardization with flexibility to meet diverse client and product needs
- Partner with product, engineering, and leadership to improve tools, workflows, and data quality
- Contribute to broader data and product strategy through scientific expertise
Requirements
- 5+ years of hands-on variant interpretation experience in a clinical or equivalent setting
- Advanced degree (PhD, MS in Genetics/Genomics) or Genetic Counselor (CGC)
- Deep expertise applying ACMG/AMP guidelines in complex scenarios
- Strong experience evaluating clinical and functional evidence from scientific literature
- Proficiency in HGVS nomenclature, including normalization and variant disambiguation
- Demonstrated ability to make independent, high-confidence scientific decisions.
Benefits
- Health insurance
- 401(k) matching
- Flexible work hours
- Paid time off
- Remote work options
Applicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard Skills & Tools
variant interpretationACMG guidelinesAMP guidelinesHGVS nomenclatureevidence evaluationSOP designQA processesdata quality managementclinical relevancefunctional studies evaluation
Soft Skills
mentoringcoachingperformance managementaccountabilityproblem-solvingteam leadershipcommunicationflexibilitycollaborationstrategic contribution
Certifications
PhD in GeneticsMS in GeneticsGenetic Counselor (CGC)