Mixed Modality Scientist – Peptide Downstream, Process Translation and Execution

Eli Lilly and Company

Peptide downstream scientist transferring purification and manufacturing processes for Lilly’s new Medicine Foundry. Supporting clinical supply readiness, scale-up, documentation, and process troubleshooting.

Posted 8/10/2026full-timeLebanon • 🇺🇸 United StatesMid-LevelSenior💰 $66,000 - $171,600 per yearWebsite

Core Competencies

Role fit

Core Competencies

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Demonstrates expertise in peptide purification and downstream manufacturing processes, including reverse-phase chromatography and TFF. Proficient in analytical techniques such as HPLC/UPLC and LC-MS, with a strong ability to analyze data and implement process improvements.

Highest-signal resume keywords

Peptide PurificationReverse-Phase ChromatographyTFF (Tangential Flow Filtration)HPLC/UPLCAnalytical Data Analysis

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills

Peptide Downstream ChemistryBatch Record CreationProcess QuantificationMass Balance AnalysisRoot Cause Analysis

Soft Skills

Cross-Functional CollaborationProblem Solving

Tools & Technologies

LC-MSGCNMR

Industry Keywords

Synthetic Peptide APIDrug SubstanceTechnical Transfer PlansSOPsQuality Events

About the role

Key responsibilities & impact

Evaluate and facilitate transfer of peptide downstream manufacturing processes from development laboratories to pilot plant operations, including kilo-scale and isolator production environments
Perform peptide purification and isolation and assess purification methods
Perform peptide downstream procedures including reverse-phase chromatography, TFF, lyophilization, and precipitation and drying
Evaluate safety of incoming procedures with safety and process engineering groups
Order and stage chemicals and obtain reference materials
Participate in setting up analytical methods
Reprocess and analyze analytical data to support fact-based decisions
Summarize and present chemistry and technical challenges
Perform familiarization executions to ensure plant readiness of process steps
Perform use-tests of key in-process materials and document Definitive Lab Trials
Maintain detailed lab notebooks and organized analytical data for technical packages and technical transfers
Author and review technical transfer plans, SOPs, batch records, campaign summary reports, and deviation reports
Identify process improvements and implement new technologies or procedures
Support process deviations, quality events, non-conformances, root cause analyses, and CAPAs
Collaborate cross-functionally to support clinical manufacturing readiness at the Lilly Medicine Foundry

Requirements

What you’ll need

B.S. or M.S. in chemistry, chemical engineering, or a related field
3+ years of experience in synthesis peptide purification and/or manufacturing environments involving synthetic peptide API or drug substance
Qualified applicants must be authorized to work full-time in the United States
Reverse-phase chromatography preferred
Working knowledge of peptide downstream chemistry and purification
Experience developing and scaling up chemical reactions using peptide purification techniques
Proficiency with peptide purification via chromatography and TFF, plus downstream conjugation and cyclization
Comfortable working with larger preparative columns, TFF, and related equipment
Experience creating batch records and conducting scale-up experiments
Experience with HPLC/UPLC, LC-MS, GC, NMR, and related analytical techniques
Experience with process quantification and mass balance for products and by-products
Familiarity with peptide upstream synthesis and cleavage, precipitation, and safe handling of solids/dry-end processing
Ability to analyze data, perform root cause analysis, and resolve technical challenges
Ability to work cross-functionally with engineers, analytical chemists, chemical technicians, safety, and quality representatives
Ability to work in manufacturing and laboratory environments
Limited domestic and international travel under 5% may be required

Benefits

Comp & perks

Company bonus depending, in part, on company and individual performance
Company-sponsored 401(k)
Pension
Vacation benefits
Medical, dental, vision, and prescription drug benefits
Flexible benefits, including healthcare and/or dependent day care flexible spending accounts
Life insurance and death benefits
Time off and leave of absence benefits
Well-being benefits, including employee assistance program, fitness benefits, and employee clubs and activities
Employee resource groups and support networks