Principal Software Engineer

eClinical Solutions

Principal Software Engineer leading the development of clinical data applications at eClinical Solutions. Focusing on scalable web applications, system architecture, and AI capabilities.

Posted 5/30/2026full-timeRemote • Massachusetts • 🇺🇸 United StatesLead💰 $152,000 - $190,000 per yearWebsite

Tech Stack

Tools & technologies

AngularASP.NETAWSAzureCloudDistributed SystemsMicroservicesMS SQL Server.NETPythonSDLCSQLTypeScript

About the role

Key responsibilities & impact

Design, develop, test, and deploy scalable, secure, and highly interactive web applications
Own and evolve core platform modules, from concept through release and support
Influence application and system architecture with a focus on performance, reliability, security, and maintainability
Lead by example through clean, well-tested code, thoughtful design reviews, and pragmatic technical decisions
Collaborate closely with Product Management, QA, and other engineers throughout the SDLC
Provide technical mentorship and guidance to other engineers on the team
Diagnose and resolve complex production issues across distributed systems
Ensure solutions meet eClinical Solutions quality standards and applicable industry regulations
Contribute to technical documentation including design specs, acceptance criteria, and release notes.

Requirements

What you’ll need

Bachelor’s or Master’s degree in Computer Science or equivalent practical experience
10+ years in software design and development using the Microsoft technology stack preferred
Expert-level proficiency in C#, .NET, and ASP.NET (MVC/Web APIs)
Strong experience building full-stack web applications (Angular, TypeScript, HTML, CSS)
Solid understanding of software design principles, patterns, and best practices
Experience across the full Software Development Lifecycle (Agile preferred)
Proven ability to work independently while collaborating effectively in a fast-paced environment
Excellent communication, documentation, and technical leadership skills.
Hands-on experience integrating LLM-based services (e.g., OpenAI, Azure OpenAI, or similar) into applications
Experience using Python and/or .NET alongside AI/LLM workflows
Familiarity with agent-based or workflow-driven AI architectures is a strong plus
Understanding of secure and responsible AI usage in enterprise systems.
Strong SQL expertise (Microsoft SQL Server preferred), including performance tuning
Experience with microservices, distributed systems, and cloud platforms (AWS preferred)
Secure development experience, including awareness of common vulnerabilities and mitigations
Experience with clinical trial data, life sciences, or regulated SaaS environments
Experience building data visualizations or analytics-driven user experiences.

Benefits

Comp & perks

Health insurance
Retirement plans
Paid time off
Flexible work arrangements
Professional development

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

C#.NETASP.NETAngularTypeScriptHTMLCSSPythonSQLmicroservices

Soft Skills

communicationdocumentationtechnical leadershipcollaborationmentorshipproblem-solvingindependencedesign reviewspragmatic decision-makingperformance tuning

Certifications

Bachelor’s degree in Computer ScienceMaster’s degree in Computer Science