Vice President, Clinical Pharmacology, Pharmacometrics, DMPK
Disc Medicine
full-time
Posted on:
Location Type: Hybrid
Location: Watertown • Massachusetts • 🇺🇸 United States
Visit company websiteJob Level
Lead
About the role
- Reporting to the Senior Vice President, Early Development and Clinical Pharmacology; establish and lead the Clinical Pharmacology, Pharmacometrics and DMPK function.
- Define strategic vision, operational frameworks, and best practices tailored to Disc Medicine’s portfolio and R&D goals.
- Lead clinical pharmacology and DMPK on cross-functional R&D teams; contribute to nonclinical and clinical development plans, study protocols, and decision-making at all stages.
- Apply quantitative methodologies including population PK/PD, exposure–response modeling, PBPK, and QSP to inform dose selection, clinical trial design, special population strategies, and regulatory submissions.
- Drive clinical pharmacology and DMPK strategy for INDs, CTAs, NDAs/BLAs; oversee authorship and review of key regulatory documents and engagement with global health authorities.
- Collaborate closely with Clinical Development, Regulatory Affairs, CMC, Innovation, Toxicology, and Biomarker teams to ensure integration of Clinical Pharmacology and DMPK throughout R&D.
- Maintain expertise in evolving approaches and represent Disc Medicine in external scientific forums, regulatory meetings, and industry collaborations.
Requirements
- PhD or PharmD in Clinical Pharmacology, DMPK, Pharmaceutical Sciences, or a related scientific discipline.
- 20+ years of relevant industry experience, including 10+ years in a leadership capacity within clinical pharmacology and/or DMPK.
- Track record of supporting research and development programs including leading Clinical pharmacology/DMPK in regulatory filings and successful interactions with global health authorities.
- Expertise in a broad range of Clinical Pharmacology and DMPK areas with comprehensive understand of the applications of modeling and simulation methodologies (e.g., popPK, PBPK, exposure–response, QSP).
- Demonstrated ability to work collaboratively in a cross-functional, matrixed environment and to influence at all levels of the organization.
- Excellent communication skills, including the ability to distill complex scientific analyses into clear, actionable recommendations.
Benefits
- comprehensive benefits
- competitive compensation packages
- flexible work environment
- dynamic hybrid role offering flexibility to work remotely and from our headquarters in Watertown, MA
- professional development
- inclusive company culture
Applicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard skills
Clinical PharmacologyDMPKPharmacometricsPopulation PK/PDExposure–Response ModelingPBPKQSPRegulatory SubmissionsClinical Trial DesignModeling and Simulation Methodologies
Soft skills
LeadershipCollaborationInfluencingCommunicationStrategic VisionOperational FrameworksBest PracticesCross-Functional TeamworkDecision-MakingActionable Recommendations
Certifications
PhDPharmD