Disc Medicine

Accounting Manager

• Play a lead role in the monthly, quarterly, and annual close processes, ensuring timely and accurate financial reporting.
• Understands and applies U.S. GAAP, has strong internal control structure understanding and has willingness to challenge current processes or procedures as a trusted business partner.
• Prepares / reviews complex journal entries, account reconciliations, and variance analyses with a high degree of accuracy managing the monthly, quarterly, and year-end close processes, ensuring timely and accurate financial reporting in accordance with US GAAP.
• Lead the monthly accrual process across research, clinical operations, CMC, G&A, and commercial functions, ensuring expense recognition reflects operational activity.
• Partner closely with FP&A, Clinical Operations, CMC, and other cross-functional teams to validate spend and inform accrual estimates.
• Develop, maintain, and review clinical accrual models for multiple clinical programs across various phases, ensuring accurate recognition of costs incurred but not yet invoiced.
• Serve as a key point of contact for interim and year-end internal and external integrated audits, preparation of schedules, performance / documentation of controls and providing supporting documents.
• Analyze and explain variances between actual results, forecasts, and budgets to management and external auditors.

Corporate Accounting Manager

Human Resources

• Design, implement, and optimize compensation, benefits, HR systems, and employee lifecycle processes
• Ensure compliance with regulatory requirements (including FDA/GxP)
• Partner closely with Finance, Legal, and external advisors for scalable infrastructure
• Manage total rewards strategy, annual compensation cycle, and external compensation consultants
• Design and manage comprehensive benefits programs, lead annual open enrollment
• Oversee and optimize end-to-end employee lifecycle processes
• Ensure HR practices comply with FDA/GxP and maintain compliance with employment laws
• Serve as system owner for ADP Workforce Now and drive reporting analytics

Executive Director, Total Rewards – HR Operations

Strategy

• Support strategic initiatives that will address mission-critical questions and position Disc for future success
• Support commercial preparation activities, including market shaping, launch planning, value proposition development, and positioning
• Monitor, understand and prioritize external trends of relevance to the company, and help determine how Disc should prepare and/or respond
• Critically evaluate available information about Disc’s diseases of interest and the competitive landscape and synthesize information succinctly to support dissemination and incorporation into clinical development programs, asset plans and therapeutic area strategy
• Support consulting and market research projects to gain deeper insight into markets of interest for Disc
• Research, evaluate and recommend potential growth strategies through expansion into new therapeutic categories, markets, and related businesses
• Lead analyses of commercial opportunities (including epidemiology modeling and detailed revenue projections) related to corporate/business development initiatives
• Support external communications, including drafting press releases and developing corporate presentations
• Maintain and update corporate website
• Assist business development processes by providing expertise for in- or out-licensing, partnering and acquisition activities, as well as contributing to deal sourcing, due diligence, and negotiations
• Support development and maintenance of Disc valuation model and supporting documents

Senior Manager, Corporate Strategy

Research Scientist

• Serve as the DMPK representative on biologics and/or small molecule project teams, providing scientific and strategic leadership.
• Design, conduct, interpret, and report in vitro ADME, in vivo PK, and PK/PD studies.
• Develop and maintain compound selection criteria to support consistent decision‑making across projects.
• Partner effectively with modeling and simulation experts, toxicologists, and clinical pharmacologists for human PKPD prediction, toxicology and clinical study support.
• Summarize and present scientific results to project teams, leadership, and broader stakeholders.
• Oversee external CRO partners to ensure high‑quality data generation within budget and timelines.
• Contribute expert‑level guidance to regulatory submissions for biologics and/or small molecules.

Principal Scientist – DMPK

Clinical Research

• Covers end-to-end study support from planning through closeout:
• Support overall management of global clinical trials (planning, execution, closeout)
• Monitor study progress, budgets, and timelines
• Assist with planning and conduct of investigator meetings
• Perform periodic visits to sites/CROs to assess study progress and protocol compliance
• Review monitoring visit reports and ensure timely resolution of action items
• Liaise with clinical sites and Investigators to maintain effective Sponsor-site relationships
• Ensures compliant, high-quality trial delivery:
• Assist in evaluation, selection, and oversight of CROs, vendors, and consultants
• Review and approve vendor-generated operational plans
• Ensure audit readiness of trial documentation (including TMF)
• Ensure compliance with GCP and regulatory requirements
• Proactively identify, manage, and mitigate study risks
• Supports regulatory documentation and business operations:
• Participate in SOP preparation and review
• Contribute to drafting and reviewing clinical documents (protocols, ICFs, IBs, reports, ASRs/DSURs, status updates)
• Support meeting coordination, agendas, minutes, and metric tracking
• Perform additional responsibilities as assigned by the line manage.

Senior Clinical Trial Manager

Recruitment

• Lead the development and execution of comprehensive patient recruitment and retention plans for US and global Phase 2/3 studies aligned with enrollment goals and timelines.
• Partner with Clinical Development and Clinical Operations Leads to design and implement study-specific recruitment and retention strategies.
• Drive study-level strategies to engage and recruit participants with appropriate demographics.
• Oversee development of compelling recruitment materials that educate and engage potential participants and sites.
• Lead initiatives to establish and manage patient referral management plans.
• Track and analyze KPIs to optimize recruitment and retention performance.
• Identify and implement innovative approaches, technologies, and industry best practices to enhance enrollment outcomes.
• Collaborate with study sites to develop tailored recruitment approaches based on local demographics.
• Maintain and lead relationships with patient engagement and advocacy organizations.
• Manage and oversee external recruitment and retention vendors.
• Partner closely with Clinical Operations, Regulatory Affairs, and Medical Affairs to ensure aligned and compliant strategies.
• Present recruitment and retention strategies to investigators, patient advocacy groups, and at industry conferences.
• Share learnings, insights, and best practices across teams to drive process improvements.
• Stay informed on emerging trends and innovative recruitment solutions; proactively educate internal stakeholders.
• Perform additional responsibilities as assigned to support evolving business needs.

Corporate Accounting Manager

Executive Director, Total Rewards – HR Operations

Senior Manager, Corporate Strategy

Principal Scientist – DMPK

Senior Clinical Trial Manager

Associate Director, Patient Recruitment and Retention