Disc Medicine

Clinical Research

• Work directly with the Medical Director and the clinical study team in the execution of early-stage Phase 1 & 2, as well as pivotal, clinical trials
• Collaborate cross-functionally with Medical Directors, Pharmacology, Innovation, Pharmacovigilance, external experts, and investigators
• Work closely with contract research organizations and the internal Disc team to strategize and meet timelines
• Monitor and review safety and efficacy data in ongoing studies with the Medical Monitor
• Represent the clinical study team at the clinical sub team and program team meetings
• Develop and maintain relationships with key opinion leaders and principal investigators
• Participate in Investigator meeting planning and execution and/or on-site initiation meetings
• Lead internal and external team members, vendors, and consultants for efficacy and safety data evaluation
• Review clinical and regulatory documents
• Organize and present at clinical advisory boards, investigator meetings, and medical/scientific meetings
• Support strategy and business development processes for licensing and acquisition activities
• Maintain awareness of internal and external developments including attendance at major scientific conferences

Senior Principal Clinical Scientist

Manager

• Provide technical support to our end-user community and consultant network as needed.
• Troubleshoot issues related to networks, applications, and operating systems (Windows 11/Intune and iOS).
• SharePoint Administration including access requests and permissions management.
• On-Site A/V meeting support (8 conference rooms) including cloud management, device updates (MS Teams), and AV vendor support requests.
• Provision and maintain IT equipment for our employees and contractors, such as laptops, printers, scanners, etc.
• Participate in the day-to-day monitoring and operational support of security solution hardware, software, managed solutions, and service provider relationships.
• Participate in improving our infrastructure, processes, procedures, and information security program.
• Stay up to date with industry trends, emerging technologies, and best practices to provide recommendations for enhancing our service offerings and infrastructure.

Manager, Information Technology

Medical Director

• Contribute to the overall clinical development strategy for assigned programs.
• Partner with the Executive Medical Director to define clinical development plans, trial designs, and program milestones.
• Provide medical and scientific input into target product profiles, study protocols, investigator brochures, and regulatory documents.
• Maintain awareness of internal and external developments (scientific, clinical, competitive, and regulatory) that could impact the development plan, including attendance at major scientific conferences, participation in competitive intelligence activities, and periodic literature review.
• Critically evaluate available information about diseases of interest to the therapeutic area and the competitive landscape and synthesize information succinctly to support dissemination and incorporation into clinical development programs, asset plans and therapeutic area strategy
• Help to determine appropriate advisory boards experts
• Serve as medical monitor for clinical trials, ensuring subject safety and data integrity.
• Provide clinical guidance to operational teams, investigators, and external partners.
• Review and interpret clinical data, prepare clinical study reports, and support publication activities.
• Be responsible for the clinical content of all clinical and regulatory documents, including protocols, INDs, CTAs, investigator brochures, CRFs, annual IND reports, CSRs, and clinical expert reports
• Organize and present at relevant clinical advisory boards, DMC and medical/scientific meetings
• Collaborate with Clinical Operations, Regulatory Affairs, Biostatistics, Pharmacovigilance, and Medical Affairs to ensure seamless execution of clinical programs.
• Represent Clinical Development in internal governance meetings and cross-functional program teams.
• Support business development and alliance management activities as needed.
• Contribute to regulatory submissions (INDs, NDAs, BLAs, etc.) and interactions with global health authorities.
• Ensure compliance with GCP, ICH guidelines, and company SOPs.
• Prepare abstracts and manuscripts for publication/presentation.
• Present clinical data to internal stakeholders, investigators, and at scientific conferences.
• Provide mentorship to junior medical or scientific staff.

• Act as the primary point of contact for day-to-day communications with the specialty pharmacy partner, supporting smooth case management processes and an optimal patient and prescriber experience
• Lead and facilitate calls and interactions with specialty pharmacy contacts to monitor patient progress, reconcile data discrepancies, research case inquiries, and provide updates to key stakeholders as needed
• Track case progress, access barriers and trends, and proactively anticipate and address challenges to support timely referral processing
• Work both independently and collaboratively with key stakeholders to resolve complex access issues, promoting positivity and teamwork
• Foster an environment of exceptional customer service to both internal and external customers, addressing requests and escalations accurately, promptly, and compliantly
• Proactively monitor patient services program health through service level agreements and key performance indicator tracking
• Drive initiatives to continuously improve patient services processes, offerings, and outcomes

Senior Manager, Access Liaison

General Counsel

• Draft, review and negotiate a range of agreements, including master service agreements, research and development agreements, license agreements, consulting agreements, confidentiality agreements, clinical trial agreements, work orders and other vendor agreements, across the company's business
• Collaborate with employees across the company with respect to contract requests in a manner that efficiently advances our corporate goals by promoting successful contract execution
• Pro-actively identify risks inherent in contract terms, including legal, financial and reputational risks, and develop practical, business-oriented solutions to appropriately mitigate such risks
• Provide legal interpretation of agreements and other related business matters and provide practical, business-oriented legal advice
• Develop and refine contract templates and assist with the administration/oversight of contract systems and processes, such as our contract management system, to ensure efficiency of operations
• Advise on other legal matters that arise across various functions within the company, as appropriate
• Interface with external legal resources, as appropriate

Director, Contracts Counsel

Research Scientist

• Characterize biologic therapeutics using standard analytical extended techniques to explore relationships between structure and function.
• Oversee development of standard protein analysis methods through external vendors and guide transfer analytical methods to separate analytical and QC testing facilities.
• Develop analytical techniques to measure product and process impurities.
• Strengthen relationships with external CDMO partners to establish and manage appropriate scopes of work.
• Provide oversight into external testing facilities for non-GMP and GMP testing.
• Lead method performance investigations, troubleshooting, and laboratory investigations.
• Working and up-to-date knowledge of ICH guidelines and other regulatory guidance.
• Author, review and edit SOPs, protocols, reports, and quality related documentation.

Principal Scientist/Associate Director, Analytical Development, Clinical Quality Control

Director

• Own end‑to‑end revenue recognition and reporting under US GAAP (ASC 606), including variable consideration estimation, roll‑forwards, and revenue analytics.
• Lead the monthly close for US product revenue: review/approve journal entries, accruals, reconciliations, and flux analyses driving on‑time and right‑first‑time results.
• Build and maintain the GTN waterfall: working with our 3rd party partner to design methodologies, set assumptions, monitor drivers (chargebacks, rebates, returns, price protection, copay, admin fees), and manage true‑ups.
• Serve as business owner for third‑party service providers (3PL, chargebacks/rebates processor, government pricing vendor, price transparency reporting partner, data aggregator).
• Set SLAs/KPIs, chair weekly operational reviews, resolve exceptions, and ensure data integrity across EDI (852/867), wholesaler data, and ERP/finance systems.
• Evaluate vendor performance, escalate issues, and drive continuous improvement and automation.
• Oversee (via vendor) all federal and state pricing programs: MDRP/Medicaid (AMP/Best Price, DDR), 340B (ceiling price), VA/FSS (NFAMP/FCP), Medicare Part B, TriCare, and state drug price transparency filings (e.g., WAC launch and price‑increase reporting).
• Govern contract & pricing data: class‑of‑trade, customer eligibility, price lists/WAC, wholesaler admin fees, and distributor agreements ensuring compliant data lineage and documentation.
• Partner with Legal/Market Access on payer and channel contracts.
• Own the annual methodology documentation, governance calendar, SOPs, and change controls.
• Oversee order‑to‑cash in partnership with 3PL/wholesalers (order management, invoicing, cash application, deductions, short‑pays).
• Ensure robust chargeback/ rebate adjudication and dispute resolution with distributors, GPOs, PBMs, and payers.
• Design key controls (SOX 404), segregation of duties, and data reconciliations across ERP, 3PL portal, and pricing systems.
• Own GTN inputs working with our service provider to translate market dynamics (payer mix, utilization, formulary wins/losses, copay trends, returns) into forecast assumptions.
• Provide clear, decision enabling insights to senior leadership running scenario analyses and sensitivities around price, mix, and channel.
• Support external reporting and quarterly/annual audits.

Associate Director, Revenue Management – Government Pricing

QA Engineer

• Provide quality partnership and oversight of Disc Medicine’s Biologics manufacturing, testing, and disposition of products.
• Support ongoing technology transfer of drug product and device manufacturing processes.
• Ensure compliance in Disc Medicine Quality Management System and CDMO manufacturing and testing operations with applicable GMP regulations.
• Collaborate with cross-functional teams to draft, review, and verify documents to Health Authority CMC submissions.
• Develop, implement and approve risk-based quality system oversight related to CDMO manufacturing and testing of combination products.
• Partner closely with internal stakeholders to ensure program alignment and timely delivery of quality milestones.
• Identify and escalate quality risks while driving effective, compliant resolutions.

Director, GMP Quality Assurance

• Partner with Disc cross-functional team members on overall account and territory strategy to maximize internal/external customer knowledge on payer policy and processes.
• Support patients pull-through with appropriate access education.
• Act as a subject matter expert on the US market access landscape. This includes payer policies, prior authorization requirements, denials, appeals, peer to peer and other education required to navigate access
• Create short-term & long-term strategic account plans focused on increasing customer knowledge and access confidence for key accounts
• Collaborate with Disc Patient Services and Orsini Specialty Pharmacy on individual case management needs related to HCP education and patient pull-through
• Assess key metrics including time to therapy to support ongoing innovation and collaborations to meet or exceed performance objectives.

Regional Access Manager

Operations

• Reporting to the Vice President, Commercial Operations, the Director, Field Support & Reporting will play a key role in supporting our first commercial launch and future growth.
• This role is responsible for driving field operations effectiveness through reporting, analytics, systems management, and process optimization.
• Define, create and produce reporting and analytics for field teams and field leadership.
• Lead incentive compensation process including design, operations, exception management, reporting.
• Lead targeting, segmentation and alignment work including development and implementation of target lists as well as alignment updates.
• Collaborate and work with internal teams and third-party vendors in supporting the operations of MDM, Data Lake, DQM, Catalog, Governance, Analytics, Commercial Reporting and any other related processes.
• Manage Veeva CRM from commercial standpoint including updating data in the CRM, responding to field requests/questions, and working with vendor and internal IT to deliver system enhancements.
• Identify and address operational problems and inefficiencies, report these to the management team and suggest solutions.

Director, Field Operations

Vice President

• Reporting to the Senior Vice President, Early Development and Clinical Pharmacology; establish and lead the Clinical Pharmacology, Pharmacometrics and DMPK function.
• Define strategic vision, operational frameworks, and best practices tailored to Disc Medicine’s portfolio and R&D goals.
• Lead clinical pharmacology and DMPK on cross-functional R&D teams; contribute to nonclinical and clinical development plans, study protocols, and decision-making at all stages.
• Apply quantitative methodologies including population PK/PD, exposure–response modeling, PBPK, and QSP to inform dose selection, clinical trial design, special population strategies, and regulatory submissions.
• Drive clinical pharmacology and DMPK strategy for INDs, CTAs, NDAs/BLAs; oversee authorship and review of key regulatory documents and engagement with global health authorities.
• Collaborate closely with Clinical Development, Regulatory Affairs, CMC, Innovation, Toxicology, and Biomarker teams to ensure integration of Clinical Pharmacology and DMPK throughout R&D.
• Maintain expertise in evolving approaches and represent Disc Medicine in external scientific forums, regulatory meetings, and industry collaborations.

Vice President, Clinical Pharmacology, Pharmacometrics, DMPK

Supply Chain

• Manage clinical supply planning and forecasting for Disc’s small molecule program
• Serve as member of the clinical study team and/or clinical drug supply team
• Review clinical study protocols to develop packaging/labeling designs, label pack timelines and distribution strategies
• Ensure supply demand is clearly communicated to the technical operations/QA team so manufacturing and release activities align with the organization timelines
• Collaborate closely with labeling and packaging CDMO’s to ensure operation dates align with clinical timelines
• Develop and maintain strong relationships with external vendor(s)/partner(s) critical to Disc objectives and deliverables
• Coordinate QP release for global studies
• Review pharmacy manuals and clinical site SOPs
• Budgeting, forecasting, and strategic planning activities for clinical trials
• Drive the sourcing of the clinical supply service provider as needed
• Coordinate the origination, translations, proofing and approval of clinical study labels
• Participate in the configuration and UAT testing of the IRT, if applicable
• Serve as primary contact and project manager for the labeling and packaging services provider associated with the clinical study
• Coordinate drug supply delivery timelines with Supply Chains operations planning, CMC and the label/pack service providers
• Monitor global clinical supply inventory at the depot and clinical site levels
• Maintain close communications with all internal groups to ensure adequate supply of clinical supplies throughout the duration of a clinical trial
• Meet with Clinical Operations as needed to update study assumptions and update supply plans
• Collaborate closely with Reg-CMC and Quality Assurance
• Serve as author and reviewer for IND and IMPD submissions, as applicable
• Provide visibility to potential risks in planned capacity and make recommendations with strategic direction
• Assist with creation or review of SOPs as needed

Associate Director, Clinical Supply Chain

• Reporting to the Vice President, Marketing
• Develop and lead Disc’s thought leader engagement strategy across all therapeutic areas and life-cycle stages
• Define prioritization of national and regional thought leaders, tailoring engagement plans by specialty, geography, and influence
• Design and execute speaker bureau strategy: speaker identification, nomination, contracting, training, and retention
• Lead strategy and engagement for key medical conferences, including developing materials and engagements
• Partner with HCP Marketing to develop peer-to-peer content that is scientifically accurate, engaging, and compliant
• Drive scientific advocacy by fostering strong relationships between thought leaders and internal stakeholders (Medical, Marketing, Access)
• Lead end-to-end planning and execution of advisory boards and roundtables, ensuring strategic objectives and high-quality insights
• Lead identification of next generation influencers and speakers
• Translate thought leader feedback into actionable recommendations to shape marketing strategies, messaging, and launch planning
• Establish clear KPIs and performance dashboards for thought leader engagement (reach, quality of insights, program effectiveness, speaker utilization, etc.)

Director, Thought Leadership Strategy and Engagement

• Report to Head of ADQC in Technical Operations and lead the clinical QC function for Disc Medicine biologics pipeline programs from early development to commercialization
• Support selection, negotiation, and review of service agreements and statements of work with analytical and QC CDMOs
• Develop and manage relationships with external CDMO partners to ensure appropriate scopes of work and program expectations
• Guide qualification and validation of analytical methods to support GMP in-process, batch release and stability studies; review and approve protocols and reports
• Establish training and technical approaches to transfer analytical methods between development and QC testing sites
• Establish and implement product specifications, oversee outsourced GMP release testing, stability programs, and reference standard management at CDMOs
• Accountable for QC OOS/OOT/deviation investigations and identification of root cause and CAPA for testing-related issues
• Support quality assurance in product release activities and product shelf-life management
• Establish systems and procedures for product and reference standard trending and review trend reports periodically
• Author, review, and approve SOPs, protocols, reports, and change controls; support annual product review and annual report activities
• Represent quality control operations in regulatory and partner audits and author/review global health authority CMC dossier sections for clinical trials and commercial licensure
• Foster a positive workplace culture that prioritizes collaboration, accountability, and continuous improvement

Director, Analytical Development and Clinical Quality Control

• Disc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients with serious hematologic diseases by targeting heme biosynthesis and iron homeostasis.
• Regional Business Director (US East) responsible for strategically building a high-performing sales team to execute the U.S. commercial launch strategy.
• Oversee Salesforce-enabled lead programs and ensure compliant, science-driven customer engagement to achieve forecasted patient demand.
• Identify, recruit, lead, and develop a regional team of Rare Disease Specialists; drive field execution of national sales strategy and achieve regional revenue targets.
• Collaborate cross-functionally (Sales Operations, Training, Marketing, Medical Affairs, Market Access, Patient Services) to maximize sales opportunities and ensure aligned HCP engagement.
• Coordinate territory and regional performance metrics, optimize CRM adoption, and serve as the field voice to headquarters.
• Represent the company at national and regional conferences and ensure compliance with relevant regulations and policies.

Regional Business Director

Marketing Operations

• Reporting to the Vice President, Marketing, the Manager, Marketing Operations will provide commercial support services including congress & sponsorship management, literature fulfillment, HCP contracting, speaker programs and patient programs leadership.
• The role will additionally have responsibility for executing specific marketing projects.
• As part of a small and evolving team, this role offers a unique opportunity to contribute across multiple areas of commercial execution.
• The ideal candidate is detail-oriented, organized, and adaptable, with a strong interest in life sciences and a hands-on approach to teamwork.
• National Conference & Sponsorship Management: Lead planning and execution of National Conferences for assigned strategic pillar(s), partnering with cross-functional teams and vendors while serving as the primary point of contact for organizers.
• Lead all cross functional planning meetings, prepare and present pre-con and post-con materials to internal attendees.
• Speaker Programs: Lead speaker bureau development, annual speaker training, and program evolution in alignment with Marketing direction.
• Support program execution, metrics and KPI reporting, compliance requirements, and Sales team needs.
• HCP Contracting: Support commercial function on contracting HCPs and processing payment in a timely manner including speaker programs, patient programs, symposia and sales training.
• Project manage all physician engagements from the initial contracting phase in conjunction with marketing through to completion of invoicing/reimbursement form and processing payment in a compliant and timely manner.
• Literature Print & Fulfillment: Act as the primary point of contact between Marketing, Sales, and vendor for promotional literature print and fulfillment.
• Manage inventory levels, dissemination, expirations and forecasting for all printed promotional items within strategic pillar(s).
• Project manage the print process through to fulfillment, from initial quoting with alignment from marketers through to sharing drop shipment tracking to field sales team.
• Attend MLR for strategic pillar(s) and agency status meetings as needed.
• General Marketing and Project Management: Assist in the preparation and submission of promotional materials through the ad promo (Medical/Legal/Regulatory) review process
• Support execution of marketing tactics under the direction of senior marketing team members (e.g., digital campaigns, sales collateral, print and promotional material production)
• Help maintain marketing calendars, timelines, and status trackers