Disc Medicine

Principal Scientist – DMPK

Disc Medicine

full-time

Posted on:

Location Type: Hybrid

Location: Watertown • Massachusetts • United States

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Salary

💰 $173,000 - $234,000 per year

Job Level

Senior

About the role

  • Serve as the DMPK representative on biologics and/or small molecule project teams, providing scientific and strategic leadership.
  • Design, conduct, interpret, and report in vitro ADME, in vivo PK, and PK/PD studies.
  • Develop and maintain compound selection criteria to support consistent decision‑making across projects.
  • Partner effectively with modeling and simulation experts, toxicologists, and clinical pharmacologists for human PKPD prediction, toxicology and clinical study support.
  • Summarize and present scientific results to project teams, leadership, and broader stakeholders.
  • Oversee external CRO partners to ensure high‑quality data generation within budget and timelines.
  • Contribute expert‑level guidance to regulatory submissions for biologics and/or small molecules.

Requirements

  • MS in DMPK, biology, chemistry, or related field with 8+ years of relevant experience, or PhD (or equivalent) with 5+ years of relevant industry experience.
  • Demonstrated expertise in large‑molecule PK, PKPD, and general discovery or development areas.
  • Strong working knowledge of ADME, PK, PKPD for small molecules is an important plus.
  • Proven ability to evaluate and apply innovative PK and PK/PD approaches to predict human PK, generate hypotheses, design studies, inform clinical plans, and support regulatory filings is highly preferred.
  • Experience working effectively and collaboratively with cross‑disciplinary teams; ability to lead, influence, and contribute to decision‑making.
  • Excellent written and verbal communication skills.
Benefits
  • Comprehensive benefits
  • Competitive compensation packages
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
DMPKADMEPKPKPDin vitro studiesin vivo studiesregulatory submissionscompound selection criteriadata generationtoxicology
Soft Skills
scientific leadershipstrategic leadershipcollaborationcommunicationdecision-makinginfluencepresentation skillsteamworkguidanceevaluation
Certifications
MS in DMPKPhD in related field