Director, HEOR

Definium Therapeutics

Director of HEOR at Definium Therapeutics supporting innovative evidence generation for brain health disorder treatments. Leading HEOR studies, collaborating cross-functionally, and communicating strategic insights.

Posted 4/29/2026full-timeRemote • 🇺🇸 United StatesLead💰 $227,109 - $255,000 per yearWebsite

About the role

Key responsibilities & impact

Leads the design, implementation and management of HEOR studies from concept development through publication. HEOR studies may include, but are not limited to, prospective research studies, patient interviews, and payer-focused tools (i.e. dossier, external facing assets)
Help identify evidence gaps and needs from regulatory, reimbursement and patient perspectives, resolve these challenges and translate strategic objectives into the HEOR / Real-World Evidence (RWE) plan
Directs the generation of necessary evidence to demonstrate product differentiation and values, and / or to support clinical development, regulatory needs through RWE and epidemiology studies in a timely and strategic manner
Work closely with other functions in cultivating strong internal partnerships, including research and development strategy, epidemiology, regulatory, policy, market access and medical affairs on the development on programs that support broad access and value
Support proactive engagement with payer advisors and KOL stakeholders including generating strategic insights on endpoints, PCOA, and trial design. Identify relevant PCOA endpoints and provide input to the clinical development plan
Psychometric validation of patient-reported outcomes and instruments
Help develop protocols for RWE (prospective and retrospective) analyses, PROs, surveys/patient interviews and provide innovative solutions on RWE for use as a synthetic/historical or concurrent control, including expertise on methodological considerations to account for confounding, missing variable, temporal or other biases and/or methodological challenges
Experience in evidence synthesis (in conducting systematic literature review, indirect treatment comparisons, gap analyses for effectiveness, meta-analysis)
Collaborate with Publications and other functions on development of real-world evidence publications for congresses and peer-reviewed journals
Provide project and vendor management support, including request for proposal, statement of work, vendor selection, legal & compliance issues, and budget tracking
Develop and maintain strong, collaborative relationships with the broader Definium organization and with external experts
Help support and manage deliverables such as value dossiers, reimbursement dossiers, reimbursement landscape analyses, consultant driven research projects
Ensure that deliverables are accomplished on time and within budget

Requirements

What you’ll need

Advanced degree (MS, MPH, MD, PhD, PharmD) in health economics, epidemiology, health services research
Minimum 5-7 years’ experience in HEOR in an industry setting, preferably in psychiatry or neuroscience related therapeutic areas
Excellent knowledge of market access environment and health technology assessment process in the U.S. and key European markets
Demonstrated experience in designing HEOR protocol elements both within phase III / non-interventional study programs and phase IV/post-marketing
Previous new product launch experience a plus
Demonstrated business and scientific acumen
Excellent analytic and problem-solving skills
Demonstrated ability to understand and effectively communicate scientific information
Ability to work independently, proven oral and written communication skills
Ability to work effectively in a fast-paced, collaborative environment
Aptitude to closely collaborate and bond with an entirely remote team, willing to travel on a regular basis for in-person team meetings (projected ~25% – 30% travel)

Benefits

Comp & perks

100% paid health benefits including Medical, Dental and Vision for you and your dependents
401(k) program with company match and vesting after the turn of the first month after your start date
Flexible time off
Generous parental leave and some fun fringe perks!

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

HEOR studiesReal-World Evidence (RWE)epidemiologypsychometric validationevidence synthesissystematic literature reviewmeta-analysisprotocol developmentpatient-reported outcomes (PROs)budget tracking

Soft Skills

analytical skillsproblem-solving skillscommunication skillscollaborationindependencebusiness acumenscientific acumenrelationship buildingtime managementadaptability

Certifications

MSMPHMDPhDPharmD