Senior Director, Real World Evidence – Center of Excellence Lead

Crinetics Pharmaceuticals

Senior Director leading Real-World Evidence program at Crinetics Pharmaceuticals. Managing a team to execute observational studies and evidence generation in healthcare.

Posted 6/11/2026full-timeRemote • California • 🇺🇸 United StatesSenior💰 $280,000 - $308,000 per yearWebsite

About the role

Key responsibilities & impact

Lead the delivery of the real-world evidence program across the portfolio, translating evidence priorities into rigorous, well-designed real-world studies.
Provide leadership, career management, coaching, and mentoring to a team of RWE Scientists; recruit and develop talent and align team capacity to portfolio demand.
Drive team objectives, prioritization, and resource allocation across competing therapeutic area needs.
Operate across long-range lifecycle planning and near-term execution horizons.
Design and oversee burden-of-illness, natural history, patient journey, drug utilization, external control arm, comparative effectiveness, and HTA-supportive real-world studies.
Contribute to the design and operationalization of Crinetics-sponsored registries and lead registry-related analytics and evidence generation.
Lead analyses using large healthcare databases and primary real-world data collection methods.
Establish methodological standards, protocol templates, statistical analysis frameworks, and quality benchmarks.
Conduct and supervise feasibility assessments, database selection, and study-design innovation.
Partner with IT and Commercial to shape enterprise real-world data sourcing and analytics infrastructure.
Lead the RWE module of CrinRADAR, supporting scalable and automated evidence generation.
Establish data governance, contracting, and vendor management standards for real-world data assets.
Partner with HEOR Therapeutic Area Leads to translate franchise-level evidence questions into executable plans.
Contribute evidence to integrated evidence plans, value dossiers, and HTA submissions.
Collaborate cross-functionally with Clinical Development, Biometrics, Regulatory, and Patient Advocacy.
Build and steward external partnerships with academic investigators, data providers, and analytics vendors.
Lead publication strategy and external scientific communication for the real-world evidence program.
Represent Crinetics at scientific congresses and remain current with evolving real-world evidence methodologies and guidance.
Ensure compliance with corporate policies and applicable healthcare laws and regulations.

Requirements

What you’ll need

Advanced degree in epidemiology, biostatistics, health services research, health economics, or related discipline (PhD, MD, PharmD, MPH, MSc)
Minimum of 13 years of relevant pharmaceutical, biotechnology, or HEOR consulting experience
Minimum of 10 years supervisory years of experience
Demonstrated expertise in designing and executing observational studies using large real-world datasets across the product lifecycle
Experience leading center-of-excellence or function-level real-world evidence programs across multiple assets
Experience building and managing external real-world data vendor partnerships
Working knowledge of regulatory and HTA evidence requirements
Experience delivering real-world evidence into value dossiers and HTA submissions
Strong analytical, quantitative, and methodological expertise
Excellent communication and interpersonal skills with the ability to influence senior leaders
Ability to lead, collaborate, and influence cross-functional teams
Flexible, adaptable, and effective in ambiguous environments.

Benefits

Comp & perks

discretionary annual target bonus
stock options
ESPP
401k match
health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance
20 days of PTO
10 paid holidays
winter company shutdown

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

real-world evidenceobservational studiesstatistical analysisdata governancemethodological standardshealthcare databasesprimary real-world data collectioncomparative effectivenessburden-of-illness studiesHTA submissions

Soft Skills

leadershipcoachingmentoringcommunicationinterpersonal skillscollaborationinfluenceflexibilityadaptabilityproblem-solving

Certifications

PhDMDPharmDMPHMSc