Senior Manager, Clinical Trial Supplies

Crinetics Pharmaceuticals

Senior Manager overseeing global clinical trial supply operations at Crinetics Pharmaceuticals. Leading supply chain strategies and collaborations across multiple clinical programs.

Posted 5/9/2026full-timeRemote • California • 🇺🇸 United StatesSenior💰 $140,000 - $175,000 per yearWebsite

About the role

Key responsibilities & impact

Develop and lead end-to-end clinical supply strategies for multiple clinical programs and phases (Phase I–IV)
Design optimized supply models, including labeling, packaging, distribution, and inventory strategies
Assess and mitigate supply risks, including demand uncertainty, enrollment variability, and manufacturing constraints
Manage clinical trial supply lifecycle activities, including forecasting, demand planning, packaging, labeling, distribution, returns, and destruction
Ensure uninterrupted supply of investigational and comparator products to global clinical sites
Manage Interactive Response Technology (IRT) system builds, UAT testing, supply strategies and reconciliation activities
Partner closely with Clinical Operations, Manufacturing, Quality, Regulatory Affairs, Finance, and external vendors as required to ensure alignment on study timelines and deliverables
Serve as the clinical supply representative on study teams and governance forums
Influence study design decisions to optimize supply chain efficiency and patient experience
Lead selection, contracting, and performance management of external vendors (CMOs, depots, couriers, IRT providers)
Develop and manage clinical supply budgets, vendor quotes, proposals, and timelines
Drive cost optimization while maintaining quality and compliance
Confirm production plans and shipping schedules; develop depot/site resupply strategies and coordinate packaging schedules with third-party provider(s) to support clinical demand changes
Work with third-party providers to develop detailed project plans and timelines for the packaging, release, and distribution of clinical supplies
Coordinate the review and approval of provider documentation (distribution instructions, label proofs, packaging specifications and methods, packaging batch records, etc.)
Plan and oversee the implementation of expiry date extensions
Coordinate the assessment of and track temperature excursions during storage, receipt, or transit to clinical sites or depots
Support the transportation and disposition of returned/unused materials, as needed
Manage activities needed to source comparators and ancillary products. Plan supply strategies, labeling and distribution activities
Support the development of Standard Operating Procedures (SOPs) and guidelines related to third-party provider management, inventory management, distribution, transportation, disposition of returned/unused materials, etc.
Support CMC team as needed
Other duties as assigned.

Requirements

What you’ll need

Minimum of a Bachelor’s in life sciences, nursing, business or related field with at least 12 years of related technical experience
Alternatively, a Master’s degree with 8 years of experience (an equivalent combination of experience and education may be considered)
Previous experience in Project Management, Pharmaceutical Development, Clinical Supply Management, and/or Clinical Trials Coordination
Previous experience in rare diseases/oral solid dosage forms is a plus
Import and export management of drug substance and drug product
Understanding of CGMP and CGCP requirements, compendia testing, and ICH and regulatory guidelines including stability data requirements
Excellent interpersonal and communication skills (written and oral)
Experience with preparation of regulatory documents is desired
Excellent ability to work in a goal and team-oriented setting and to handle competing priorities
Flexibility within a rapidly changing environment and high attention to details
Well-developed organizational skills and the ability to thrive under pressure
Well-versed in industry trends, emerging business processes and technologies.

Benefits

Comp & perks

discretionary annual target bonus
stock options
ESPP
401k match
top-notch health insurance plans for employees (and their families) to include medical, dental, vision and basic life insurance
20 days of PTO
10 paid holidays
winter company shutdown

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

clinical supply strategiessupply modelsrisk assessmentdemand planningInteractive Response Technology (IRT)clinical trial supply lifecyclecost optimizationproject managementregulatory document preparationinventory management

Soft Skills

interpersonal skillscommunication skillsteam-orientedflexibilityattention to detailorganizational skillsability to handle competing prioritiesthrive under pressureinfluence decisionscollaboration