Chan Zuckerberg Initiative

Principal Technical Program Manager, SciTech

Chan Zuckerberg Initiative

full-time

Posted on:

Location Type: Hybrid

Location: Redwood City • California • 🇺🇸 United States

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Salary

💰 $214,000 - $268,000 per year

Job Level

Lead

About the role

  • Owns, leads and drives large, and highly impactful programs; accountable for planning strategy and execution.
  • Coordinate multidisciplinary teams in the planning, execution, and scaling of complex AI engineering projects that bridge scientific discovery and translational application, with direct alignment to biological use cases.
  • Manage AI engineering’s model roadmap and ensuring new models from across the CZI ecosystem are staffed with the appropriate AI engineering teams and have access to our GPU cluster.
  • Proactively identify scalability bottlenecks and dependencies, and implement mitigation plans to enable sustainable, widespread technology use.
  • Serve as a liaison between scientific researchers, product managers, research engineers, data scientists, and computational biologists to ensure successful technology transfer and scaling pathways in biological model development.
  • Manage execution of AI projects such as production-grade AI agents development, benchmarking, model inference, and model contribution in close partnership with engineering leads.
  • Define and execute AI-based biological workflows, for example using agents to uncover biological insights working closely with cross-functional stakeholders.
  • Communicate project milestones and risks clearly to stakeholders across technical and non-technical domains.
  • Track impact metrics including publications, platform performance, and adoption metrics across both research and industry ecosystems.

Requirements

  • Advanced degree in a scientific discipline or MBA.
  • Experience at a leading AI-first biotech company.
  • Familiarity with bio-specific PM challenges.
  • 12+ years leading complex technical programs, with 3+ years deploying AI/ML in project execution (biotech/life sciences preferred).
  • Demonstrated experience driving the adoption of novel technologies across diverse environments, including managing validation pipelines, documentation, user training, and feedback loops.
  • Proven track record in coordinating partnerships or consortia that span academic institutions, biotech, and/or commercial organizations.
  • Experience implementing programmatic strategies that enable sustainable growth and technology scalability.
  • Excellent systems thinking, with the ability to bridge scientific innovation with practical implementation and stakeholder alignment.
  • Strong communication skills and the ability to influence and align diverse technical and non-technical partners around scale-up strategies.
Benefits
  • CZI provides a generous employer match on employee 401(k) contributions to support planning for the future.
  • Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs.
  • CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them.
  • Paid time off to volunteer at an organization of your choice.
  • Funding for select family-forming benefits.
  • Relocation support for employees who need assistance moving to the Bay Area
  • And more!

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard skills
AI engineeringmodel roadmap managementproduction-grade AI developmentbenchmarkingmodel inferencebiological workflowsscalability mitigationvalidation pipelinesuser trainingfeedback loops
Soft skills
leadershipcommunicationsystems thinkingstakeholder alignmentinfluenceproject managementcross-functional collaborationstrategic planningproblem-solvingadaptability
Certifications
advanced degree in scientific disciplineMBA
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