Scientific Software Developer II – Modeler

Cadence Design Systems

Computational Chemist/Cheminformatician developing features for OpenEye’s Orion platform. Collaborating with mathematical and medicinal chemistry experts to support pharmaceutical projects.

Posted 4/30/2026full-timeSanta Fe • Massachusetts, New Mexico • 🇺🇸 United StatesMid-LevelSeniorWebsite

Tech Stack

Tools & technologies

Python

About the role

Key responsibilities & impact

Extend OpenEye’s programming toolkits by developing and implementing new and useful scientific and technical features to aid customers in developing bespoke solutions.
Explore methods for further enhancing OpenEye’s virtual screening platform (including OMEGA, ROCS, FastROCS, OEDocking).
Apply chemistry/cheminformatics expertise with ML experts to build robust, scalable models to support data-driven decision making.
Work on retrospective and prospective projects both internally and with collaborators to validate methodologies.
Work with Orion project team to further optimize compound design workflows in Orion.

Requirements

What you’ll need

PhD (or equivalent experience) in computational chemistry, chemistry, cheminformatics, or related field with 0 – 3 years relevant experience
Knowledge of some traditional computational chemistry approaches such as docking, virtual screening, molecular modeling, etc.
Programming expertise, ideally in c++ and/or python preferably with experience using AI coding agents
Experience in or desire to learn about the pharmaceutical industry
Strong desire to find practical solutions to challenging problems
Demonstrated ability to work both as part of a team and independently

Benefits

Comp & perks

medical
dental
vision
flexible working schedule
401k retirement plans
paid vacation
paid sick leave
home internet costs
public transportation reimbursement

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

programmingC++Pythoncomputational chemistrycheminformaticsmolecular modelingdockingvirtual screeningmachine learningdata-driven decision making

Soft Skills

problem solvingteamworkindependencecollaborationcommunicationadaptabilitycreativitycritical thinkinganalytical skillsdesire to learn

Certifications

PhD in computational chemistryPhD in chemistryPhD in cheminformatics