Principal Scientist, Computational Biology

Bristol Myers Squibb

. Perform computational research and integrative analyses on multimodal biological profiling datasets (e.g.

Posted 4/29/2026full-timeCambridge • Massachusetts, Washington • 🇺🇸 United StatesLead💰 $156,890 - $202,086 per yearWebsite

Tech Stack

Tools & technologies

Python

About the role

Key responsibilities & impact

Perform computational research and integrative analyses on multimodal biological profiling datasets (e.g. transcriptomic, proteomics, single cell omics, spatial profiling) to support early pipeline programs
Apply machine learning, and other advanced computational/ statistical approaches, to compare high-dimensional experimental readouts from perturbation experiments/screens (e.g. CRISPR screens, perturb-seq, cellular imaging) to disease states defined by patient data and work as part of a cross-functional team to nominate and validate new targets for Neuro, Cardiovascular and autoimmune diseases indications
Work with external partners in industry, academia, and pre-competitive collaborations (e.g. NIH Accelerating Medicines Partnership) on novel computational and experimental approaches
Communicate findings and recommend follow-up actions in multiple settings (including 1:1, seminars, and team meetings)

Requirements

What you’ll need

Principal Scientist
Bachelor's Degree in computational biology, computational genomics/genetics, computer science, statistics, mathematics, or other related discipline
8+ years of academic / industry experience or Master's Degree in computational biology, computational genomics/genetics, computer science, statistics, mathematics, or other related discipline 6+ years of academic / industry experience or PhD in computational biology, computational genomics/genetics, computer science, statistics, mathematics, or other related discipline 4+ years of academic / industry experience
Advanced hands-on knowledge of at least one high-level programming language such as R or Python for computational research and reproducible research practices
5+ years of post-graduate experience in computational biology research (biopharma industry preferred) with track record (such as scientific publications) in driving and advancing research projects/programs with computational approaches
Hands on experience analyzing and integrating high-dimensional molecular datasets such as multi-omics (RNA-seq, ATAC-seq, proteomics, ChIP-seq/CUT&RUN ), single cell (CITE-seq, scATAC-seq, perturb-seq)
Hands on experience on spatial profiling (Xenium, Visium, GeoMx, CosMX ) data analyses and interpretation
Experience implementing and/or developing statistical methodologies and machine learning algorithms applied to the biological problems
Background in human disease biology, especially in areas of neurodegenerative disease, cardiovascular diseases and autoimmune diseases strongly preferred
Experience applying computer vision models to cellular imaging data preferred
Experience utilizing and applying AI agent such as claude coding to accelerate workflow preferred
Scientific curiosity with an ability of self-learning
Strong oral and written communication skills.

Benefits

Comp & perks

Health Coverage: Medical, pharmacy, dental, and vision care.
Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays.)
Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays.
Based on eligibility*, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.

ATS Keywords

✓ Tailor your resume

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools

computational researchintegrative analysesmachine learningstatistical methodologieshigh-level programming languageRPythonmulti-omicsspatial profilingcomputer vision models

Soft Skills

scientific curiosityself-learningoral communicationwritten communication

Certifications

Bachelor's DegreeMaster's DegreePhD