Director, Health Economics – Outcomes Research (HEOR)

BioNTech SE

Global HEOR Director driving impactful health economics and outcomes research strategies at BioNTech. Collaborating with cross-functional teams to enhance market access and reimbursement success.

Posted 5/30/2026full-timeMaryland, New Jersey, Virginia • 🇺🇸 United StatesLead💰 $168,100 - $268,700 per yearWebsite

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Hard Skills

systematic literature reviewsindirect treatment comparisonscost-effectiveness analysesbudget impact analysesreal-world evidencepatient-reported outcomesepidemiology literature reviewsevidence synthesis strategieshealth economicsstudy design evaluation

Soft Skills

communication skillsmentoringcollaborationconstructive feedbackleadership

Tools & Technologies

FDA regulationseCOA implementationKomodoOptumMedicare RIF

Certifications & Qualifications

MSPhDPharmDMD

Industry Keywords

HEOR researchglobal value evidenceEU-HTA requirementsJSCEAJCAHTA marketspediatric investigation plansadvisory boardsDelphi panels

Tech Stack

Tools & technologies

Delphi

About the role

Key responsibilities & impact

Develop and execute Global value evidence generation plans for systematic literature reviews (SLR), indirect treatment comparisons (ITC), cost-effectiveness analyses (CEA), budget impact analyses (BIA), real-world evidence (RWE), and patient-reported outcomes (PRO) to optimize clinical development decisions across all stages of drug development
Conduct global epidemiology literature reviews to inform multi-regional clinical trial site selection and recruitment strategies
Provide guidance on FDA regulations related to patient-reported outcomes (PROs) and patient-focused drug development (PFDD), ensuring alignment with labeling claims
Prepare regulatory-grade documents such as FDA/Global Regulatory briefing books for PRO Endpoint implementation, epidemiology, and pediatric investigation plans
Lead the implementation of robust evidence synthesis strategies to support global pharmaceutical launches and reimbursement dossiers across HTA markets & Non HTA Markets like PICOS Simulation/Scoping, PICOS feasibility assessment and development JCA dossiers
Lead the development of early advice (EA) dossiers (Country level and JSC) and actively participate in discussion with relevant stakeholders on the value of the clinical program
Stay at the forefront of industry trends and integrate emerging methodologies into evidence synthesis plans including the use of AI in SLR/ITCs/ RWE and Global Value Evidence tool kit development
Collaborate with key opinion leaders, including medical experts, through structured engagements like advisory boards and Delphi panels
Develop pre-approval dossiers, launch models (CEA/BIA), tools, relevant Health Care Economic Information (HCEI) training materials to support US Account Management teams, Medical Science Liaisons, and field-based HEOR professionals
Support other HEOR team members by reviewing their evidence generation plans, publications and offering constructive- solution oriented feedback
Mentor HEOR fellows and early-career team members while providing constructive feedback on evidence generation plans

Requirements

What you’ll need

MS required; Doctoral degree (PhD/PharmD/MD) preferred in Public Health, Epidemiology, Health Economics, or related fields with significant experience conducting HEOR research
At least 5 years of relevant experience (or 10 years with MS degree) conducting HEOR research across methodologies such as SLR, ITC/NMA/MAIC/STC, CEA/BIA models, RWE designs, and PRO analytics
Expertise in US/Ex-US real-world data sources (e.g., Komodo, Optum, Medicare RIF) with proficiency in study design evaluation and improvement
Experience with eCOA implementation preferred; familiarity with FDA COA Type C meetings and negotiating PRO label claims a plus
Proven track record of peer-reviewed publications showcasing HEOR expertise across multiple domains
Deep understanding of EU-HTA requirements including JSC/EA/JCA implementation alongside knowledge of global health technology assessment guidelines
Excellent communication skills with experience presenting HEOR research to payers/population health decision-makers

Benefits

Comp & perks

Competitive remuneration packages
Benefits in support of our diverse employee base that may include health insurance, retirement plans, paid time off, flexible working arrangements, professional development, bonuses, stock options, equipment allowances, wellness programs