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BioCryst Pharmaceuticals, Inc.

Senior Systems Engineer

BioCryst Pharmaceuticals, Inc.

Sr. Systems Engineer at BioCryst Pharmaceuticals supporting Microsoft cloud services and on-premises infrastructure.

Posted 7/30/2026full-timeDurham • North Carolina • 🇺🇸 United StatesSeniorWebsite

Core Competencies

Role fit
Core Competencies

Use this summary to align your resume positioning with the role.

Demonstrates expertise in designing, implementing, and supporting Microsoft enterprise cloud platforms and services, with a strong focus on security, compliance, and operational excellence. Proven ability to lead infrastructure initiatives and collaborate with managed service providers to optimize cloud and on-premises environments.

Highest-signal resume keywords
Microsoft 365 AdministrationAzure Solutions ArchitectCloud Security ManagementEnterprise NetworkingTechnical Leadership

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills
Microsoft AzureMicrosoft 365SharePoint OnlineExchange OnlineTeamsPurviewEntra IDCisco MerakiInfrastructure OperationsDisaster Recovery
Soft Skills
Analytical SkillsTroubleshootingCommunicationProblem-Solving
Tools & Technologies
Conditional AccessMulti-Factor Authentication (MFA)Privileged Identity Management (PIM)VPNsFirewalls
Certifications & Qualifications
Azure Administrator AssociateAzure Solutions Architect ExpertMicrosoft 365 Administrator Expert
Industry Keywords
GxPSOXRegulated EnvironmentsCloud-First Enterprise

Tech Stack

Tools & technologies
AzureCloudFirewallsSwitching

About the role

Key responsibilities & impact
  • Design, administer, support, and optimize Microsoft enterprise cloud platforms and services, including Microsoft 365, Azure, SharePoint Online, Exchange Online, Teams, Purview, and Entra ID
  • Provide operational support and lead the evaluation, testing, and rollout of new features and service enhancements while ensuring platform availability, performance, reliability, and user adoption
  • Serve as the technical owner for Microsoft enterprise cloud platforms and services, establishing standards, evaluating new capabilities, and ensuring solutions align with business, operational, security, and compliance requirements
  • Architect and deliver solutions that address business and operational needs, serving as the technical lead for the successful implementation of technology initiatives and process improvements
  • Administer and support on-premises infrastructure at the Durham location, including networking, wireless, switching, internet connectivity, firewalls, and related infrastructure systems
  • Participate in after-hours maintenance and support activities as required
  • Provide onsite infrastructure support five days per week within the Durham office location
  • Partner with the company's managed service providers (MSPs) to monitor, maintain, and troubleshoot cloud and infrastructure services
  • Partner with Information Security, Compliance, and IT teams to implement, maintain, and optimize Microsoft cloud identity, access, security, governance, and compliance controls
  • Coordinate with Microsoft, service providers, and third-party vendors to troubleshoot issues, evaluate solutions, and ensure service performance and support expectations are met
  • Create and maintain technical documentation, standards, procedures, diagrams, and knowledge articles

Requirements

What you’ll need
  • 7+ years of experience supporting enterprise Microsoft cloud platforms, infrastructure, and networking environments
  • Bachelor's degree in Information Technology, Computer Science, Engineering, or a related field
  • Demonstrated expertise designing, implementing, and supporting Microsoft enterprise cloud platforms and services, including Microsoft 365, Azure, Exchange Online, SharePoint Online, Teams, Purview, and Entra ID
  • Strong understanding of Microsoft cloud identity, security, governance, compliance, and access management technologies, including Entra ID, Conditional Access, MFA, Privileged Identity Management (PIM), Microsoft Purview, retention, information protection, and lifecycle management solutions
  • Experience evaluating, testing, deploying, and integrating Microsoft cloud capabilities and service enhancements within a cloud-first enterprise environment
  • Working knowledge of Cisco Meraki, enterprise networking, wireless technologies, firewalls, routing, VPNs, and hybrid cloud infrastructure
  • Working knowledge of server, backup, disaster recovery, monitoring, and infrastructure operations
  • Experience working with managed service providers (MSPs), Microsoft support, and third-party technology vendors
  • Proven ability to serve as a technical lead, driving infrastructure and cloud initiatives from design through implementation
  • Strong analytical, troubleshooting, communication, and problem-solving skills
  • Experience supporting GxP, SOX, and other regulated environments preferred
  • Microsoft certifications such as Azure Administrator Associate, Azure Solutions Architect Expert, Microsoft 365 Administrator Expert, or equivalent certifications strongly preferred.

Benefits

Comp & perks
  • Health insurance
  • Flexible working hours
  • Professional development opportunities