Director, Clinical Pharmacology

BBOT

Director or Senior Director providing scientific and strategic leadership across oncology pipeline at BridgeBio. Overseeing clinical pharmacology strategy and collaborating with cross-functional teams.

Posted 7/3/2026full-timeRemote • 🇺🇸 United StatesSenior💰 $200,000 - $280,000 per yearWebsite

About the role

Key responsibilities & impact

Lead the clinical pharmacology strategy for one or more oncology programs, ensuring alignment with regulatory requirements and scientific standards
Design and oversee clinical pharmacology studies to support assigned oncology programs’ clinical development plans
Collaborate with cross-functional teams, including clinical development and operations, biostatistics, and regulatory affairs, to drive the advancement of drug development programs
Drive application of model-informed drug development (MIDD) approaches, including population PK/PD and exposure–response analyses
Author relevant sections/modules of regulatory documents (including INDs, IBs, CTAs, IMPDs, NDAs, briefing packages, or other regulatory dossiers) and serve as subject matter expert in regulatory interactions with FDA and other global health authorities
Interpret and communicate clinical pharmacology data and results to internal teams, health authorities, and external stakeholders
Partner with biostatistics and data management to establish analysis datasets, statistical analysis plans, and reporting standards for PK/PD endpoints
Contribute to dose selection and dosing regimen optimization across programs, leveraging exposure–response relationships and emerging clinical data
Provide clinical pharmacology input into study protocols, informed consent forms, and clinical study reports
Stay abreast of industry trends and advancements in clinical pharmacology and oncology, contributing to the scientific community through presentations and publications
Participate in cross-functional team meetings, providing clinical pharmacology insights and updates to internal stakeholders

Requirements

What you’ll need

Ph.D. or equivalent in pharmacokinetics (PK)/pharmacodynamics (PD), Pharmacology, Chemistry, or a related field
Minimum 8 years of experience in clinical pharmacology, particularly with small molecule modalities within the oncology therapeutic area
Proven track record of successfully managing clinical pharmacology studies and developing regulatory submissions
Strong understanding of oncology drug development processes and regulatory guidelines, including FDA and global health authority requirements
Quantitative pharmacology skillset preferred, e.g., PBPK, PK/PD modeling, population PK, and exposure–response analyses
Experience authoring clinical pharmacology sections of regulatory dossiers (INDs, NDAs, CTAs, briefing packages)
Excellent communication and interpersonal skills, with the ability to work collaboratively in a cross-functional team environment
Prior experience in a lean or startup environment is highly desirable.

Benefits

Comp & perks

annual bonus
stock-based long-term incentives
medical, dental, and vision benefits
retirement
wellness stipend
flexible time off

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Hard Skills & Tools

Clinical Pharmacology StrategyPopulation PK/PD ModelingExposure–Response AnalysisRegulatory Document AuthoringDose Selection OptimizationStatistical Analysis PlansClinical Study Protocol DevelopmentData Management CollaborationIND/NDA Submission ExperiencePharmacology Data Interpretation

Soft Skills

Excellent Communication SkillsInterpersonal SkillsCollaborative Teamwork