Axle Informatics

Bioinformatics Engineer

Axle Informatics

full-time

Posted on:

Location Type: Remote

Location: United States

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Salary

💰 $125,000 - $150,000 per year

About the role

  • Evaluate existing bioinformatics pipelines for performance, accuracy, and maintainability, identifying opportunities for optimization and enhancement
  • Develop, extend, and maintain Nextflow workflows for bulk RNA-seq, single-cell RNA-seq, DNA variant calling, methylation analysis, and emerging assay types
  • Architect scalable solutions capable of processing thousands of samples efficiently on Google Cloud Platform
  • Optimize data input/output operations across pipeline modules to minimize bottlenecks and reduce computational costs
  • Prepare and structure analysis outputs for visualization platforms and downstream statistical or machine learning applications
  • Implement best practices for workflow versioning, containerization, testing, and documentation
  • Collaborate with computational biologists, data scientists, and software engineers to integrate pipelines into broader analytical ecosystems
  • Stay current with advances in sequencing technologies and analytical methods, evaluating and incorporating new tools as appropriate

Requirements

  • Master's degree in bioinformatics, computational biology, computer science, or a related field (or equivalent experience)
  • 3+ years of hands-on experience developing and maintaining bioinformatics pipelines in a production environment
  • Proficiency with Nextflow (DSL2) and familiarity with workflow management concepts
  • Strong experience with RNA-seq analysis (both bulk and single-cell) and DNA sequencing workflows (variant calling, methylation)
  • Working knowledge of Google Cloud Platform services (Compute Engine, Cloud Storage, Batch, Life Sciences API, or similar)
  • Proficiency in Python and/or R for scripting, data manipulation, and tool development
  • Experience with containerization technologies (Docker, Singularity)
  • Familiarity with version control systems (Git) and CI/CD practices
  • Strong understanding of genomic file formats (FASTQ, BAM, VCF, BED) and common bioinformatics tools (STAR, Salmon, BWA, GATK, Bismark, Cell Ranger, Seurat, Scanpy)
Benefits
  • 100% Medical, Dental & Vision Coverage for Employees
  • Paid Time Off and Paid Holidays
  • 401K match up to 5%
  • Educational Benefits for Career Growth
  • Employee Referral Bonus
  • Flexible Spending Accounts: Healthcare (FSA), Parking Reimbursement Account (PRK), Dependent Care Assistant Program (DCAP), Transportation Reimbursement Account (TRN)
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
NextflowRNA-seq analysisDNA sequencing workflowsPythonRDockerSingularityGitFASTQBAM