Oncology Translational Medicine Lead Director

AstraZeneca

Oncology Translational Medicine Lead Director developing biomarker strategies for ADC assets. Collaborating across clinical and discovery teams to enhance oncology drug development.

Posted 7/31/2026full-timeWaltham • Maryland, Massachusetts • 🇺🇸 United StatesSenior💰 $183,768 - $275,653 per yearWebsite

Core Competencies

Role fit

Core Competencies

Use this summary to align your resume positioning with the role.

Demonstrates expertise in defining and delivering biomarker strategies for oncology drug development, with a strong focus on assay design, data analysis, and collaboration with clinical teams. Proven ability to manage complex projects and influence external stakeholders effectively.

Highest-signal resume keywords

PhD Or MD In Oncology Drug Development5 Years Relevant ExperienceOncology Disease Area BiologyAssay Design And ImplementationProject Management And Execution

ATS Keywords

Tailor your resume

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills

Biomarker Strategy DevelopmentAssay ValidationData AnalysisPharmacodynamic BiomarkersTumor Microenvironment AnalysisClinical Sample InterpretationRelapse Biopsy AnalysisTranslational ScienceDisease Linkage Data SynthesisClinical Study Report Authoring

Soft Skills

Problem SolvingRisk ManagementAttention To DetailCollaborative WorkingMotivating And Developing Others

Industry Keywords

Solid TumorsClinical OperationsBiospecimen PlansLab ManualsGovernance PresentationsPublications Contribution

About the role

Key responsibilities & impact

Define and deliver end-to-end biomarker strategies for ADC assets from Phase 1 to Phase 3, aligning assays and analyses to decision points.
Generate and synthesize disease linkage data to prioritize indications and patient segments with the highest probability of benefit.
Design, validate, and implement assays to quantify target engagement and pharmacodynamic biomarkers.
Interpret pathway interactions, feedback loops, and tumor microenvironment features in clinical samples.
Lead analyses of relapse biopsies and longitudinal samples to define mechanisms of resistance.
Partner with clinical operations and study teams to specify biospecimen plans, lab manuals, and protocols.
Drive data reviews; author and review clinical study reports; present to governance; contribute to publications.

Requirements

What you’ll need

PhD and/or MD with experience in oncology drug development.
A minimum of 5 years’ of relevant experience
In-depth knowledge of oncology disease area biology (solid tumors) and translational science.
Ability to drive, manage, execute and deliver results for complex multi-functional projects.
Highly developed problem solving and risk management skills, and attention to detail.
Highly developed collaborative working skills.
Ability to act as an external ambassador and to influence external organisations to enhance the image and reputation of AstraZeneca.
Proven ability to motivate and develop others.

Benefits

Comp & perks

qualified retirement programs
paid time off (i.e., vacation, holiday, and leaves)
health, dental, and vision coverage in accordance with the terms of the applicable plans