Principal Software Engineer

Amgen

Principal Software Engineer at Amgen leading architecture and development of enterprise applications. Focus on front-end technologies and AI integration for innovative user experiences.

Posted 6/11/2026full-timeRemote • 🇺🇸 United StatesLead💰 $144,424 - $195,397 per yearWebsite

Tech Stack

Tools & technologies

JavaScriptMicroservicesNext.jsNode.jsPythonReactTypeScript

About the role

Key responsibilities & impact

Lead the architecture, design, and delivery of enterprise web applications using modern frontend and backend technologies
Develop highly interactive user experiences using React, TypeScript, Next.js, and modern frontend frameworks
Define and evolve enterprise frontend architecture, design systems, reusable component libraries, and UI engineering standards to ensure consistency, scalability, accessibility, and exceptional user experiences across applications
Design and implement AI-powered applications leveraging Generative AI, Large Language Models (LLMs), Retrieval-Augmented Generation (RAG), and agentic architectures
Build intelligent assistants, copilots, and conversational interfaces for Contracting, Pricing, and Commercial Operations users
Partner with business stakeholders to identify opportunities for automation, AI enablement, workflow optimization, and digital transformation
Lead rapid prototyping and proof-of-concept initiatives to validate emerging technologies, AI capabilities, and business use cases
Provide technical leadership and mentorship across engineering teams, driving architecture governance, engineering excellence, DevOps maturity, and adoption of modern development and AI-enabled engineering practices.

Requirements

What you’ll need

Doctorate degree and 2 years of Information Systems experience OR Master’s degree and 4 years of Information Systems experience OR Bachelor’s degree and 6 years of Information Systems experience OR Associate’s degree and 10 years of Information Systems experience OR High school diploma / GED and 12 years of Information Systems experience
5+ years of hands-on experience building frontend applications using React and modern JavaScript/TypeScript frameworks
5+ years of backend development experience using Node.js and/or Python
3+ years leading engineering teams or technical delivery teams
3+ years developing AI-powered applications using Generative AI and LLM technologies
Experience building RAG-based solutions leveraging enterprise data sources
Experience designing and developing RESTful APIs and microservices
Experience integrating enterprise SaaS platforms and business applications
Experience working in Agile product development environments.

Benefits

Comp & perks

A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions
group medical, dental and vision coverage
life and disability insurance
flexible spending accounts
A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible.

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Hard Skills & Tools

ReactTypeScriptNext.jsNode.jsPythonGenerative AILarge Language ModelsRetrieval-Augmented GenerationRESTful APIsmicroservices

Soft Skills

technical leadershipmentorshipworkflow optimizationdigital transformationarchitecture governanceengineering excellenceDevOps maturity

Certifications

Doctorate degreeMaster’s degreeBachelor’s degreeAssociate’s degreeHigh school diploma / GED