Amgen

Senior Scientist – Computational Discovery, Translational Analytics

Amgen

full-time

Posted on:

Location Type: Office

Location: South San FranciscoCaliforniaMassachusettsUnited States

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Salary

💰 $146,404 - $198,076 per year

Job Level

Tech Stack

About the role

  • Develop and apply advanced computational methods to enable target discovery, validation, and biomarker identification across multimodal datasets
  • Integrate diverse biological data types, including bulk, single-cell, and spatial omics
  • Identify cell-type-specific and disease-relevant targets and characterize their cellular context
  • Characterize gene function, pathway dependencies, and mechanisms of action
  • Develop and apply computational frameworks for variant-to-gene-to-function inference
  • Translate computational analyses into clear, testable biological hypotheses
  • Collaborate closely with experimental scientists, computational biologists, and cross-functional teams
  • Drive digital innovation by identifying gaps in analytical workflows and developing robust solutions.

Requirements

  • PhD in computational biology, bioinformatics, statistics, computer science, data science, or a related quantitative discipline [and relevant post-doc where applicable]
  • Or Master’s degree and 3 years of directly related experience
  • Or Bachelor’s degree and 5 years of directly related experience
  • Strong foundation in computational biology methods, including statistical modeling and AI/ML
  • Experience working with large-scale biological data, including long-read RNA sequencing, single-cell multi-omics, spatial omics, perturbation screens (e.g., Perturb-seq), translatomics (e.g., Ribo-Seq), proteomics, and/or epigenomic data (e.g., Hi-C, ATAC-seq)
  • Proven ability to develop novel computational methods that generate tractable biological insights from integrating complex datasets
  • Familiarity with disease tissue biology
  • Strong programming skills in Python, R, or similar languages
  • Creative, open-minded, and passionate about research.
  • Excellent communication and collaboration skills.
Benefits
  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions
  • group medical, dental and vision coverage
  • life and disability insurance
  • flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible.
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
computational biologybioinformaticsstatistical modelingAI/MLlong-read RNA sequencingsingle-cell multi-omicsspatial omicsperturbation screenstranslatomicsproteomics
Soft Skills
communicationcollaborationcreativityopen-mindednesspassion for research
Certifications
PhD in computational biologyMaster’s degreeBachelor’s degree