Amgen

Senior Principal AI/ML Scientist, Computational Imaging

Amgen

full-time

Posted on:

Location Type: Remote

Location: United States

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Salary

💰 $NaN per year

Job Level

About the role

  • Lead the design, development, training, and validation of AI/ML models for digital pathology and/or radiology applications
  • Define technical direction for custom AI/ML model development, including architecture selection, training paradigms, validation strategies, and performance benchmarks
  • Develop custom deep learning architectures and workflows for segmentation, classification, representation learning, and prediction tasks
  • Leverage and adapt foundation models (e.g., vision transformers, multimodal and self-supervised models), including fine-tuning and domain adaptation using proprietary datasets
  • Extract insights from large-scale imaging datasets, including whole-slide images and radiology modalities (CT, MRI, PET)
  • Apply advanced computer vision and machine learning methods, including CNNs, U-Net variants, Vision Transformers, diffusion-based or representation-learning models
  • Define appropriate evaluation strategies and ensure analytical rigor, reproducibility, and scientific credibility
  • Integrate imaging data with clinical, molecular, or spatial-omics data where relevant
  • Balance innovation with practicality, ensuring solutions are scalable, interpretable, and fit-for-purpose
  • Work closely with pathologists, radiologists, clinicians, and translational scientists to translate scientific questions into computational imaging solutions
  • Clearly communicate modeling approaches, assumptions, results, and limitations to technical and non-technical stakeholders
  • Contribute to shaping project-level research questions and study designs involving imaging data
  • Support external collaborations through technical input and scientific exchange as needed
  • Contribute to the organization’s scientific visibility through publications, presentations, and internal knowledge sharing
  • Provide informal mentorship and technical guidance to junior scientists and collaborators
  • Stay current with advances in AI, computer vision, and medical imaging to continuously elevate technical approaches.

Requirements

  • Doctorate degree in Computer Science, Artificial Intelligence, Machine Learning, Electrical Engineering, Computational Biology, or a related quantitative field and 3 years of related experience
  • Or Master’s degree in Computer Science, Artificial Intelligence, Machine Learning, Electrical Engineering, Computational Biology, or a related quantitative field and 6 years of related industry experience
  • Or Bachelor’s degree in Computer Science, Artificial Intelligence, Machine Learning, Electrical Engineering, Computational Biology, or a related quantitative field and 8 years of related industry experience
  • Demonstrated deep technical expertise in developing custom AI/ML models for medical imaging
  • Strong experience in digital pathology and/or radiology, including whole-slide images and/or modalities such as CT, MRI, or PET
  • Expertise in foundation model usage, including pre-training, fine-tuning, and domain adaptation for imaging-based tasks
  • Advanced knowledge of modern computer vision and ML techniques, including: CNNs, U-Net–based architectures, Vision Transformers, Self-supervised, weakly supervised, and few-shot learning, Multimodal and representation learning approaches
  • Proficiency in Python and deep learning frameworks such as PyTorch and/or TensorFlow.
  • Demonstrated ability to communicate complex technical concepts clearly and influence scientific decision-making
  • Strong record of scientific contributions (e.g., publications, patents, deployed models, or platform capabilities)
  • Demonstrated evidence of setting and implementing technical or scientific strategies for complex AI/ML or computational imaging initiatives, including defining problem statements, selecting modeling approaches, and driving execution to measurable scientific or translational outcomes
  • Strong publication record in AI/ML, with particular emphasis on applications to drug development, biomarker discovery, patient stratification, or translational research; contributions to high-impact journals or top-tier AI/medical imaging conferences strongly preferred
  • Experience working with integrated imaging, clinical, and molecular datasets
  • Familiarity with MLOps, scalable training, and model lifecycle management
  • Experience with cloud or HPC environments (e.g., AWS, Azure, GCP, SLURM), containerization, and distributed training
  • Prior experience leading significant components of cross-functional or external collaboration.
Benefits
  • A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions
  • group medical, dental and vision coverage
  • life and disability insurance
  • flexible spending accounts
  • A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models where possible.
Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools
AI/ML model developmentdeep learning architecturescomputer visionCNNsU-NetVision TransformersPythonPyTorchTensorFlowdomain adaptation
Soft Skills
communicationmentorshipcollaborationinfluenceanalytical rigorscientific credibilityinnovationproblem-solvingtechnical guidanceproject management