Principal Scientist – Translational Pharmacology

5AM Ventures

Director of Translational Pharmacology leading preclinical pharmacology efforts in innovative science. Translating findings into actionable pharmacology strategies in the biotech sector.

Posted 4/24/2026full-timeEmeryville • California • 🇺🇸 United StatesLead💰 $180,000 - $230,000 per yearWebsite

About the role

Key responsibilities & impact

Lead the design, execution, and interpretation of preclinical pharmacology studies supporting drug discovery and development programs
Develop and apply quantitative PK/PD models, integrating pharmacokinetics, pharmacodynamics, and chemical kinetics to guide compound optimization and dosing strategies
Design and oversee in vivo studies, including selection and development of appropriate animal models
Drive rigorous data analysis, including statistical evaluation and modeling to inform decision-making
Translate preclinical findings into clinically relevant hypotheses and development strategies
Collaborate closely with teams to optimize drug candidates and delivery systems
Contribute to regulatory documentation and strategy (IND-enabling studies, study reports, etc.)
Build and manage relationships with CROs and external collaborators

Requirements

What you’ll need

PhD, MD, or equivalent in pharmacology, biomedical sciences, or related field
Significant experience in preclinical pharmacology within biotech or pharmaceutical settings
Experience in choosing appropriate animal models
Deep expertise in PK/PD modeling, with strong grounding in chemical kinetics and quantitative biology
Proven experience designing studies to evaluate drug combinations and synergy, including application of factorial experimental design Demonstrated experience designing and interpreting in vivo pharmacology studies
Experience in advancing preclinical candidates through IND-enabling studies and contributing meaningfully to IND submissions
Strong statistical and data analysis skills
Experience in metabolic diseases, particularly obesity and/or diabetes, strongly preferred

Benefits

Comp & perks

🌐 Worldwide ❌ Jobs You've Hidden ⭐️ Saved Jobs ✅ Applied Jobs ✉️ Email Alerts 👤 Account 5AM Ventures Website LinkedIn All Job Openings 11 - 50 employees 5AM was founded in 2002 and pursues investments in advanced life science innovations, and seeks to be diversified across the biopharmaceutical therapeutics, and platform technologies. Within each sector, 5AM invests across multiple therapeutic areas and modalities and evaluates opportunities based on innovative platform technologies, corporate spin-offs and products with shorter development cycles. Principal Scientist – Translational Pharmacology 🔥 9 minutes ago 🏢🏡 Emeryville – Hybrid 💵 $180k - $230k / year ⏰ Full Time 🔴 Lead 🧬 Research Scientist Apply Now Find Hiring Managers Customize resume for this job Report problem ☆ Save ☑️ Mark as applied ❌ Hide 📋 Description
Lead the design, execution, and interpretation of preclinical pharmacology studies supporting drug discovery and development programs
Develop and apply quantitative PK/PD models, integrating pharmacokinetics, pharmacodynamics, and chemical kinetics to guide compound optimization and dosing strategies
Design and oversee in vivo studies, including selection and development of appropriate animal models
Drive rigorous data analysis, including statistical evaluation and modeling to inform decision-making
Translate preclinical findings into clinically relevant hypotheses and development strategies
Collaborate closely with teams to optimize drug candidates and delivery systems
Contribute to regulatory documentation and strategy (IND-enabling studies, study reports, etc.)
Build and manage relationships with CROs and external collaborators 🎯 Requirements
PhD, MD, or equivalent in pharmacology, biomedical sciences, or related field
Significant experience in preclinical pharmacology within biotech or pharmaceutical settings
Experience in choosing appropriate animal models
Deep expertise in PK/PD modeling, with strong grounding in chemical kinetics and quantitative biology
Proven experience designing studies to evaluate drug combinations and synergy, including application of factorial experimental design Demonstrated experience designing and interpreting in vivo pharmacology studies
Experience in advancing preclinical candidates through IND-enabling studies and contributing meaningfully to IND submissions
Strong statistical and data analysis skills
Experience in metabolic diseases, particularly obesity and/or diabetes, strongly preferred Apply Now 📊 Check your resume score for this job Improve your chances of getting an interview by checking your resume score before you apply. Check Resume Score 🌐 Worldwide Built by Lior Neu-ner. I'd love to hear your feedback — Get in touch via DM or support@remoterocketship.com Search Search Jobs by country Search jobs by city Search jobs by job title Search entry-level jobs Search junior-level jobs Search senior-level jobs Search jobs by tech stack Search jobs by contract type Search remote internships Search remote part-time jobs Remote jobs Anywhere in the World Companies Hiring Anywhere in the World Companies Hiring Sales People Anywhere in the World Companies Hiring Software Engineers Anywhere in the World Resources Advice Tips for finding remote jobs Interview questions and answers Resume examples Cover letter examples Post a job Affiliates Privacy policy Terms of service Job board SEO course AI Apply Copilot OpenClaw job finder Jobs by Country Remote jobs anywhere in the world (Worldwide remote jobs) Remote jobs United States Remote jobs Australia Remote jobs Brazil Remote jobs Canada Remote jobs France Remote jobs Ireland Remote jobs Germany Remote jobs Netherlands Remote jobs Spain Remote jobs UK Popular Jobs Remote data analyst jobs Remote customer support jobs Remote executive assistant jobs Remote marketing jobs Remote product designer jobs Remote product manager jobs Remote project manager jobs Remote recruiter jobs Remote sales jobs Remote software engineer jobs Jobs by Type Remote full-time jobs Remote part-time jobs Remote contract jobs Remote internship jobs Remote entry-level jobs Remote jobs with no experience required Remote junior jobs (1-3 years of experience) Digital nomad jobs Remote jobs with no degree required Freelance remote jobs Temporary remote jobs Remote jobs hiring now Stay at home mom jobs

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Hard Skills & Tools

preclinical pharmacologyPK/PD modelingchemical kineticsquantitative biologystudy designdata analysisstatistical evaluationin vivo studiesanimal modelsIND-enabling studies

Soft Skills

collaborationrelationship managementdecision-making

Certifications

PhDMD