5AM Ventures

Research Scientist

• Lead the design, execution, and interpretation of preclinical pharmacology studies supporting drug discovery and development programs
• Develop and apply quantitative PK/PD models, integrating pharmacokinetics, pharmacodynamics, and chemical kinetics to guide compound optimization and dosing strategies
• Design and oversee in vivo studies, including selection and development of appropriate animal models
• Drive rigorous data analysis, including statistical evaluation and modeling to inform decision-making
• Translate preclinical findings into clinically relevant hypotheses and development strategies
• Collaborate closely with teams to optimize drug candidates and delivery systems
• Contribute to regulatory documentation and strategy (IND-enabling studies, study reports, etc.)
• Build and manage relationships with CROs and external collaborators

Principal Scientist – Translational Pharmacology

Director

• Define and execute DMPK strategies across discovery and early development programs
• Design and interpret in vitro and in vivo studies to guide compound optimization and candidate selection
• Lead PK/PD modeling and exposure-response analyses to inform dosing strategies and translational plans
• Provide scientific leadership in understanding ADME properties
• Partner closely with medicinal chemistry, biology, and project teams to integrate DMPK insights into compound design and program decisions
• Contribute to program strategy discussions, helping prioritize compounds and guide advancement decisions
• Collaborate with toxicology and clinical teams to ensure alignment across preclinical and translational efforts
• Identify, select, and manage CRO partners and consultants to execute DMPK studies with high quality and efficiency
• Oversee study design, data interpretation, and reporting from external partners
• Support IND-enabling activities, including preparation of DMPK sections for regulatory filings

Principal Scientist – Translational Pharmacology

Director – Drug Metabolism & Pharmacokinetics (DMPK)