Director – Drug Metabolism & Pharmacokinetics (DMPK)

5AM Ventures

Director/Senior Director overseeing DMPK strategies from discovery through clinical studies at Renasant Bio. Collaborating with medicinal chemistry and biology to drive drug development pipelines.

Posted 4/16/2026full-timeBoston • California, Massachusetts • 🇺🇸 United StatesSenior💰 $215,000 - $275,000 per yearWebsite

About the role

Key responsibilities & impact

Define and execute DMPK strategies across discovery and early development programs
Design and interpret in vitro and in vivo studies to guide compound optimization and candidate selection
Lead PK/PD modeling and exposure-response analyses to inform dosing strategies and translational plans
Provide scientific leadership in understanding ADME properties
Partner closely with medicinal chemistry, biology, and project teams to integrate DMPK insights into compound design and program decisions
Contribute to program strategy discussions, helping prioritize compounds and guide advancement decisions
Collaborate with toxicology and clinical teams to ensure alignment across preclinical and translational efforts
Identify, select, and manage CRO partners and consultants to execute DMPK studies with high quality and efficiency
Oversee study design, data interpretation, and reporting from external partners
Support IND-enabling activities, including preparation of DMPK sections for regulatory filings

Requirements

What you’ll need

Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Drug Metabolism, or related discipline
12+ years of industry experience in DMPK within biotech or pharmaceutical settings
Demonstrated success advancing small molecule programs from discovery through IND
Deep expertise in ADME, human PK simulations, PK/PD modeling, and translational science
Experience working in or with early-stage companies, with comfort operating in resource-constrained, fast-paced environments
Strong track record of managing external CROs and consultants, and delivering high-quality data
Excellent communication skills, with the ability to influence cross-functional teams and leadership.

Benefits

Comp & perks

🌐 Worldwide ❌ Jobs You've Hidden ⭐️ Saved Jobs ✅ Applied Jobs ✉️ Email Alerts 👤 Account 5AM Ventures Website LinkedIn All Job Openings 11 - 50 employees 5AM was founded in 2002 and pursues investments in advanced life science innovations, and seeks to be diversified across the biopharmaceutical therapeutics, and platform technologies. Within each sector, 5AM invests across multiple therapeutic areas and modalities and evaluates opportunities based on innovative platform technologies, corporate spin-offs and products with shorter development cycles. Director – Drug Metabolism & Pharmacokinetics (DMPK) 🔥 10 minutes ago 🏢🏡 Boston – Hybrid 💵 $215k - $275k / year ⏰ Full Time 🟠 Senior 👔 Director Apply Now Find Hiring Managers Customize resume for this job Report problem ☆ Save ☑️ Mark as applied ❌ Hide 📋 Description
Define and execute DMPK strategies across discovery and early development programs
Design and interpret in vitro and in vivo studies to guide compound optimization and candidate selection
Lead PK/PD modeling and exposure-response analyses to inform dosing strategies and translational plans
Provide scientific leadership in understanding ADME properties
Partner closely with medicinal chemistry, biology, and project teams to integrate DMPK insights into compound design and program decisions
Contribute to program strategy discussions, helping prioritize compounds and guide advancement decisions
Collaborate with toxicology and clinical teams to ensure alignment across preclinical and translational efforts
Identify, select, and manage CRO partners and consultants to execute DMPK studies with high quality and efficiency
Oversee study design, data interpretation, and reporting from external partners
Support IND-enabling activities, including preparation of DMPK sections for regulatory filings 🎯 Requirements
Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Drug Metabolism, or related discipline
12+ years of industry experience in DMPK within biotech or pharmaceutical settings
Demonstrated success advancing small molecule programs from discovery through IND
Deep expertise in ADME, human PK simulations, PK/PD modeling, and translational science
Experience working in or with early-stage companies, with comfort operating in resource-constrained, fast-paced environments
Strong track record of managing external CROs and consultants, and delivering high-quality data
Excellent communication skills, with the ability to influence cross-functional teams and leadership. Apply Now 📊 Check your resume score for this job Improve your chances of getting an interview by checking your resume score before you apply. Check Resume Score Similar Jobs Associate Director, Analytical Development 🕒 2 days ago Apogee Therapeutics 51 - 200 🧬 Biotechnology 💊 Pharmaceuticals Website LinkedIn All Job Openings Associate Director leading analytical development focusing on monoclonal antibodies and biologics at Apogee Therapeutics. Collaborate across teams to manage multiple drug development activities. 🏢🏡 Boston – Hybrid 💵 $175k - $195k / year 💰 $149M Series B on 2022-12 ⏰ Full Time 🟠 Senior 👔 Director Senior Director, Clinical Pharmacology, Pharmacometrics 🕒 3 days ago Bicara Therapeutics 51 - 200 🧬 Biotechnology 💊 Pharmaceuticals Website LinkedIn All Job Openings Senior Director leading clinical pharmacology and pharmacometrics strategy for drug development at Bicara Therapeutics. Focus on dose selection and regulatory submissions across biologics development. 🏢🏡 Boston – Hybrid 💵 $276k - $346k / year ⏰ Full Time 🟠 Senior 👔 Director Director, Thought Leadership 🕒 4 days ago Ameriprise Financial Services, LLC 5001 - 10000 💸 Finance 💳 Fintech Website LinkedIn All Job Openings Director developing and marketing differentiated investment insights for Columbia Threadneedle Investments. Collaborating across teams to produce actionable thought leadership for clients in North America. 🏢🏡 Boston – Hybrid 💵 $138k - $186k / year ⏰ Full Time 🟠 Senior 👔 Director Payer Platform Delivery Lead – Director 🕒 4 days ago PwC 10,000+ employees 💸 Finance ☁️ SaaS Website LinkedIn All Job Openings Director leading the strategy, development, and continuous improvement of a scalable healthcare analytics platform at PwC. Mentoring future leaders and managing client relations for impactful results. 🏢🏡 Boston – Hybrid 💵 $155k - $410k / year 💰 Grant on 2023-09 ⏰ Full Time 🟠 Senior 👔 Director 🦅 H1B Visa Sponsor Senior Director, Enterprise Strategy 🕒 April 3 Zelis 1001 - 5000 ⚕️ Healthcare Insurance 💸 Finance Website LinkedIn All Job Openings Senior Director of Enterprise Strategy at Zelis modernizing healthcare financial experiences. Driving strategic development and competitive positioning across various business units. 🏢🏡 Boston – Hybrid 💵 $204k - $258.4k / year 💰 $20.1M Venture Round on 2020-01 ⏰ Full Time 🟠 Senior 👔 Director 🦅 H1B Visa Sponsor View More Director Jobs 🌐 Worldwide Built by Lior Neu-ner. I'd love to hear your feedback — Get in touch via DM or support@remoterocketship.com Search Search Jobs by country Search jobs by city Search jobs by job title Search entry-level jobs Search junior-level jobs Search senior-level jobs Search jobs by tech stack Search jobs by contract type Search remote internships Search remote part-time jobs Remote jobs Anywhere in the World Companies Hiring Anywhere in the World Companies Hiring Sales People Anywhere in the World Companies Hiring Software Engineers Anywhere in the World Resources Advice Tips for finding remote jobs Interview questions and answers Resume examples Cover letter examples Post a job Affiliates Privacy policy Terms of service Job board SEO course AI Apply Copilot OpenClaw job finder Jobs by Country Remote jobs anywhere in the world (Worldwide remote jobs) Remote jobs United States Remote jobs Australia Remote jobs Brazil Remote jobs Canada Remote jobs France Remote jobs Ireland Remote jobs Germany Remote jobs Netherlands Remote jobs Spain Remote jobs UK Popular Jobs Remote data analyst jobs Remote customer support jobs Remote executive assistant jobs Remote marketing jobs Remote product designer jobs Remote product manager jobs Remote project manager jobs Remote recruiter jobs Remote sales jobs Remote software engineer jobs Jobs by Type Remote full-time jobs Remote part-time jobs Remote contract jobs Remote internship jobs Remote entry-level jobs Remote jobs with no experience required Remote junior jobs (1-3 years of experience) Digital nomad jobs Remote jobs with no degree required Freelance remote jobs Temporary remote jobs Remote jobs hiring now Stay at home mom jobs

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Hard Skills & Tools

DMPK strategiesin vitro studiesin vivo studiesPK/PD modelingexposure-response analysesADME propertiescompound optimizationIND-enabling activitiesdata interpretationregulatory filings

Soft Skills

scientific leadershipcollaborationcommunicationinfluenceprioritizationdecision-makingproject managementteam integrationproblem-solvingadaptability

Certifications

Ph.D. in PharmacokineticsPh.D. in Pharmaceutical SciencesPh.D. in Drug Metabolism