Director – Drug Metabolism & Pharmacokinetics (DMPK)
5AM Ventures
full-time
Posted on:
Location Type: Hybrid
Location: Boston • California • Massachusetts • United States
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Salary
💰 $215,000 - $275,000 per year
Job Level
About the role
- Define and execute DMPK strategies across discovery and early development programs
- Design and interpret in vitro and in vivo studies to guide compound optimization and candidate selection
- Lead PK/PD modeling and exposure-response analyses to inform dosing strategies and translational plans
- Provide scientific leadership in understanding ADME properties
- Partner closely with medicinal chemistry, biology, and project teams to integrate DMPK insights into compound design and program decisions
- Contribute to program strategy discussions, helping prioritize compounds and guide advancement decisions
- Collaborate with toxicology and clinical teams to ensure alignment across preclinical and translational efforts
- Identify, select, and manage CRO partners and consultants to execute DMPK studies with high quality and efficiency
- Oversee study design, data interpretation, and reporting from external partners
- Support IND-enabling activities, including preparation of DMPK sections for regulatory filings
Requirements
- Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Drug Metabolism, or related discipline
- 12+ years of industry experience in DMPK within biotech or pharmaceutical settings
- Demonstrated success advancing small molecule programs from discovery through IND
- Deep expertise in ADME, human PK simulations, PK/PD modeling, and translational science
- Experience working in or with early-stage companies, with comfort operating in resource-constrained, fast-paced environments
- Strong track record of managing external CROs and consultants, and delivering high-quality data
- Excellent communication skills, with the ability to influence cross-functional teams and leadership.
Applicant Tracking System Keywords
Tip: use these terms in your resume and cover letter to boost ATS matches.
Hard Skills & Tools
DMPK strategiesin vitro studiesin vivo studiesPK/PD modelingexposure-response analysesADME propertiescompound optimizationIND-enabling activitiesdata interpretationregulatory filings
Soft Skills
scientific leadershipcollaborationcommunicationinfluenceprioritizationdecision-makingproject managementteam integrationproblem-solvingadaptability
Certifications
Ph.D. in PharmacokineticsPh.D. in Pharmaceutical SciencesPh.D. in Drug Metabolism