Executive Director – Preclinical and Translational Sciences

4D Molecular Therapeutics

Executive Director leading preclinical and translational sciences for innovative gene therapies at 4D Molecular Therapeutics. Driving strategy and managing a team for successful drug development.

Posted 4/30/2026full-timeRemote • 🇺🇸 United StatesLead💰 $270,000 - $342,000 per yearWebsite

About the role

Key responsibilities & impact

Set, communicate and drive strategy for Translational products in alignment with the broader organization of 4DMT
Prioritize and allocate resources, both within Translational and beyond, to meet portfolio needs
Lead the decision-making process with other relevant functional group heads regarding indications, targets and products’ progression from concept, design, preclinical development and Phase 1-2 clinical testing.
Provide input on scientific strategy from the earliest consideration of new targets through development, including risk, scientific challenges, timing of resource investment and development of go/no go decisions
Direct and coordinate the implementation of preclinical study programs for pharmacology studies in support of the lead to candidate optimization process
Design, implement and write-up comprehensive series of pharmacology studies to address preclinical exposure, develop pharmacokinetics and pharmacodynamics profiles and generate GLP toxicology and bio-distribution packages suitable for supporting IND filings
Manage budgets and headcounts
Design, implement and manage externally facing in vivo studies with CROs and academic centers, including drafting proposals, budget oversight and managing deliverables
Resource planning; hiring and mentoring talents; building the team and technical capabilities
Build collaborations with relevant functions at 4DMT; represent own function at the corporate level and externally
Provide direct hands-on responsibility for all Translational interactions as well as grant writing and management with rare disease advocacy groups
Participate on project teams and direct activities to ensure regulatory compliance of pre-clinical and clinical research activities
Support regulatory affairs in their preparation, review and submission of necessary pre-clinical and clinical regulatory information to regulatory agencies worldwide
Contribute to defining of clear human POC study outcome criteria for decision-making on new product candidates
Contribute senior level expertise to alliance, business development, due diligence exercises with external entities and licensing meetings as well as other critical external interfaces such as public health regulatory bodies
Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time

Requirements

What you’ll need

PhD, MD/PhD, MD or equivalent
12+ years of relevant preclinical and/or translational sciences experience within the Biotech or similar industry
4+ years of management experience or other specific work experience
Experience with preclinical, translational, and clinical R&D
Prior leadership position/s within the pharmaceutical/biotech industry or academic medical centers, with a significant history of research and translational experience
Reputation for inspiring a culture of continuous improvement, innovation and quality, leading and mentoring at the highest level of achievement.
Team leadership skills and experience in a matrixed organization
Strong communication skills both written and oral with demonstrated ability to present ideas, information, and data effectively via one-on-one discussions, team meetings, and presentations to executive leadership
Excellent time management skills and the ability to adapt to changing priorities
Self-starter who proactively establishes effective working relationships and builds partnerships with other disciplines.
Adaptability, flexibility, independence and resourcefulness; as an active participant in a vibrant small company culture, rolls up sleeves and manages multiple activities in parallel.
Ability to proactively identify challenges; possesses strategic foresight and implements appropriate courses of action
Excellent verbal and written communication skills.

Benefits

Comp & perks

Health insurance
Retirement plans
Flexible work arrangements
Professional development opportunities

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

preclinical developmenttranslational sciencespharmacology studiespharmacokineticspharmacodynamicsGLP toxicologybio-distribution packagesregulatory compliancegrant writingclinical R&D

Soft Skills

team leadershipstrong communicationtime managementadaptabilityflexibilityindependenceresourcefulnessstrategic foresightmentoringinspiring culture

Certifications

PhDMDMD/PhD