Translator

• Understands, synthesizes, and aligns biomarker and translational needs across Discovery and Development portfolios, including anticipated timing, in partnership with the Translational biomarker leads and cross-functional stakeholders
• Works with Translational, Biomarker, and cross-functional partners within a matrixed environment to ensure strategy is supported by executable plans, appropriate timelines, and realistic assumptions
• Maintains accurate portfolio data in enterprise databases
• Summarizes portfolio metrics, issues and documents/presentations for senior management/governance committees to inform decision-making, with a focus on strategy and execution of Translational work
• Provides our company's organizational and process expertise to teams to enable navigation of discovery, development, and corporate governance and business requirements
• Collaborates effectively with functional areas, support functions, and alliance partner functions (if applicable) to facilitate project/portfolio delivery
• Manages strategic, cross-functional or cross-divisional management, governance, or alliance committees
• Prepares for, facilitates, and documents outcomes of leadership team meetings, ensuring meetings have clear purpose and objectives and that conflict is surfaced and resolved
• Proactively identifies and helps address opportunities for process improvement in translational biomarker workflows, tools, and systems
• Provides mentoring, coaching, and oversight to Specialist/Senior Specialist project/Portfolio Managers working on common projects
• Actively participates and completes ongoing training and personal development activities to increase leadership competency and to gain knowledge and skill in the discipline of project/portfolio management and the business and science of pharmaceutical product discovery and development and associated translational activities
• Partners with Finance to ensure resource/budget planning and management

Associate Director, Discovery and Translational Portfolio Management

• Provide consecutive and/or simultaneous Mandarin-English interpretation during medical appointments, assessments, care planning meetings, and other resident interactions.
• Ensure accurate, complete, and confidential interpretation in accordance with professional standards and HIPAA regulations.
• Promote effective communication between healthcare providers and patients while maintaining impartiality and professionalism.
• Document interpreter services as required.

Interpreter, Mandarin/Cantonese - Per Diem

• Provide ASL interpretation services for clients and staff in person & remotely as needed
• Travel to appointments and assignments as required
• Adhere to all HIPAA requirements and professional Code of Ethics
• Participate in continuing education and professional training for interpreters

Interpreter, ASL

• Own and execute end-to-end translational strategies for assigned B-cell malignancy programs from preclinical through Phase 1/2 and, as needed, Phase 3, with clear decision points tied to dose, schedule and patient selection.
• Integrate human genetics, expression and clinical data to define indications, stratify patients and refine target populations across monotherapy and rational combinations.
• Design and interpret target engagement and pharmacodynamic biomarker readouts to enable data-driven dose selection and early proof of mechanism across multiple concurrent studies.
• Define and investigate mechanisms of resistance using longitudinal and relapse samples to inform next-line strategies and combination hypotheses.
• Analyze B-cell tumor biology, pathway interactions and microenvironment features in patient samples to guide combination design and strengthen translational rationale.
• Lead development, validation and deployment of fit-for-purpose assays (e.g., flow cytometry, IHC/IF, molecular, MRD-adjacent panels) internally and with external labs/CROs, aligned to clinical endpoints and timelines.
• Embed biomarker strategies and endpoints into protocols, sample manuals and statistical plans; partner with biosamples and precision diagnostics to ensure collection, traceability and, where relevant, CDx path alignment.
• Represent Translational Medicine on cross-functional teams, connect insights across the B-cell portfolio to inform indication expansion and combinations, and contribute to governance materials, study reports and Go/No-Go recommendations.
• Contribute translational and biomarker content for health authority interactions and filings; build coherent scientific narratives; present internally and in external forums to shape the field in B-cell translational research.

Associate Director, Translational Medicine Lead

• Act as the translational medicine lead for assigned early Oncology programs (preclinical to Phase 1): define and own biomarker and translational strategies, plans and decision-enabling datasets.
• Identify cutting edge science and technological advances and incorporate them into biomarker strategies to guide indication selection, patient enrichment, and combination strategies.
• Develop program-specific translational plans including hypothesis-driven biomarker selection, assay strategy (fit-for-purpose), sample collection/handling, and statistical/analysis plans.
• Provide scientific input into target validation and discovery phases, pharmacology, PK/PD, target engagement, mechanism-of-action and patient selection strategies across modalities.
• Lead assay selection, qualification/validation strategy and oversight (internal and external CROs/diagnostic partners); ensure data quality and regulatory/compliance readiness.
• Integrate preclinical model data with clinical development plans, informing dose selection, biomarker endpoints and translational go/no-go criteria.
• Serve as the primary cross-functional interface for translational questions—represent translational perspectives in program governance, clinical project teams, and portfolio reviews.
• Translate complex scientific evidence into clear risk/benefit and go-to-clinic recommendations for portfolio decision-making.
• Prepare and present translational updates, sections for clinical protocols, investigator brochures, regulatory briefing documents and scientific reports.
• Mentor and support the development of junior scientists; contribute to team capability building and knowledge sharing.
• Manage external scientific partnerships (academic collaborators, CROs, diagnostics vendors) to deliver assays, sample logistics and high-quality data.
• Contribute to resource planning, budgets and timelines for translational activities for assigned programs.

Director – Oncology Early Translational Biomarkers

• Serve as the primary scientific expert and internal champion for one or more immunology disease areas
• Translate deep mechanistic understanding of immune pathology into actionable therapeutic hypotheses and target identification strategies
• Maintain a current and comprehensive view of the competitive landscape, emerging science, and unmet medical need across assigned disease areas
• Represent CSL Behring at key scientific conferences, advisory boards, and KOL meetings; build and leverage a broad external network of thought leaders, clinical investigators, and academic collaborators
• Drive end-to-end asset progression from ideation through first-in-disease designation, integrating scientific rationale, translational endpoints, patient population selection, and regulatory strategy
• Lead or co-lead target and asset evaluation activities including preclinical data package reviews, mechanism-of-action assessments, and translational feasibility analyses
• Provide scientific input to IND-enabling studies, proof-of-concept study designs, and Phase 1/1b protocol development
• Collaborate with the discovery and translational teams to define disease-relevant biomarkers, pharmacodynamic readouts, and patient stratification strategies for early clinical programs
• Actively contribute to R&D programs as a subject matter expert and provide guidance for the clinical development pathway
• Partner with Business Development to assess in-licensing, partnering, and acquisition opportunities within the immunology space, providing scientific due diligence leadership
• Contribute to Target Product Profiles (TPPs), integrated development plans, and portfolio reviews
• Provide disease area expertise to regulatory submissions, clinical study reports, and scientific communications
• Work collaboratively with Medical Affairs, Clinical Operations, and translational colleagues to align development strategies.

Senior Director, Immunology and Translation

• Lead efforts to develop and integrate modern data infrastructure, analytics platforms, and visualization capabilities to support New Approach Methodologies (NAMs) and broader translational safety initiatives across the organization.
• Design, develop, and maintain scalable data infrastructure and visualization solutions supporting NAMs initiatives and other TSRS workflows
• Develop and implement databases and registries using tools such as Databricks
• Collaborate with cross-functional partners, including scientific, data engineering, IT, and AI/ML teams to harmonize and standardize data structures across nonclinical and clinical safety domains.
• Define metadata standards and ontology mappings for model systems, assays, samples, readouts, validation status, and context of use
• Support data governance, data quality, and reproducibility best practices across TSRS platforms
• Conceptualize, design, and build interactive dashboards and visualizations using platforms such as Spotfire to enable AI-supported and data-driven decision-making
• Translate complex scientific and technical concepts into clear visualizations and actionable insights for diverse stakeholders
• Develop pipelines and workflows to integrate NAMs data and other internal data with enterprise datasets, such as clinical data, via AI/ML
• Apply AI/ML approaches to support translational safety analyses, predictive modeling, and emerging NAMs applications

Senior Scientist – Translational Safety, Risk Sciences

• Develop translational strategies designed to support clinical development plans, the regulatory path, and product commercialization.
• Lead the development and implementation of translational imaging strategies in support of clinical proof-of-mechanism, patient stratification, dose selection.
• Serve as the neuroimaging lead on cross-functional program teams.
• Partner with Research to discover and characterize novel imaging biomarkers in preclinical studies.
• Develop imaging methods and analytically validate imaging tools for clinical use.
• Implement clinical biomarkers and ensure biomarker-driven decision-making across all phases of drug development.
• Lead cross-functional imaging governance (e.g., Imaging Steering Committee) advancing the use of imaging biomarkers to enable demonstration of disease-modifying effects.
• Deliver subject matter expertise with respect to clinically advanced techniques in MRI, PET, SPECT, HRCT and other modalities as needed.
• Oversee CRO vendor/partners ensuring that they optimally execute clinical and preclinical imaging projects in the US, Canada, and other regions of interest.
• Provide support for the Business Development organizations as needed on diligence efforts.

Director, Translational Medicine, Imaging

• serve as expert PK/PD modeler in cross-functional teams, to make model-informed decisions about drug discovery, modality selection, and dose prediction across therapeutic areas
• integrate in vitro and in vivo data to build PBPK, quantitative systems pharmacology (QSP), or other mechanistic modeling platforms of drug disposition and pharmacology, to support forward / reverse translation for both established and novel therapeutic targets
• guide software developers in the design of automated workflows for implementing modeling platforms, to inform human PK/PD and dose projections
• collaborate across the PDMB organization to develop modeling and simulation strategies to identify and optimize drug candidates
• provide scientific guidance and cross-functional supervision to a team of growing scientists
• mentor / supervise junior colleagues to perform the above duties and to grow the above capabilities.

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