Research Scientist

• Leading the development, optimization, and validation of spatial genomics and molecular profiling assays to support neuroscience, oncology, and immunology programs.
• Designing and executing experimental workflows involving tissue processing, immunohistochemistry, in situ hybridization, microscopy, high‑resolution slide imaging and sequencing.
• Establishing and refining new molecular assays, including troubleshooting, workflow development, and technical feasibility assessments.
• Building and scaling laboratory infrastructure, including lab setup, instrumentation planning, and operational readiness.
• Managing CROs and external partners, ensuring high‑quality data generation, timeline alignment, and technical deliverables.
• Collaborating closely with therapeutic area teams to translate multiomics and spatial readouts into actionable biological insights.
• Contributing to data workflows by supporting early-stage data mapping, QC frameworks, and analytical handoffs to computational teams.

Principal Scientist, Spatial Omics

• Manage and contribute to the coordination of multiple projects related to the scientific evaluation of a range of integrative therapies
• Work with a Project Manager to finalize study protocols
• Oversee communications with IRBs
• Recruit patients, administer phone screens, administer informed consent, enroll patients
• Perform data collection, interpretation, and manuscript preparation
• Manage the experience of subjects throughout a study

Research Assistant II

• Evaluate and develop improvements to quantum error correction strategies, algorithms, and software to enable practical execution of applications on quantum hardware
• Develop software components to handle QEC details in quantum circuit compilation, emulation/simulation, and resource estimation
• Develop or integrate real-time decoder technologies into HPE's HPC-QC software stack
• Contribute to HPC-QC architecture decisions with detailed knowledge of quantum error correction strategies
• Create and demonstrate novel quantum error correction components and describe these in publications and presentations
• Extend open-source software and improve quantum circuit compilation and simulation capabilities
• Demonstrate workflow strategies for applications that combine high performance and quantum computing, and participate in standardization of key interfaces

Senior QEC Researcher – Integrated HPC & Quantum Solutions

• Lead translational pharmacology activities across multiple Aging and Metabolism programs from target validation through candidate selection and early clinical translation.
• Drive scientific strategy and critical decision-making through integration of disease biology, pharmacology, biomarkers, human genetics, and clinical data.
• Contribute to portfolio prioritization, governance reviews, and evaluation of external innovation opportunities.
• Establish and manage collaborations with academic institutions, Contract Research Organizations (CROs), biotechnology companies, and other external partners.
• Present scientific strategies and recommendations to senior leadership and governance committees.
• Provide leadership for target validation, mechanism-of-action studies, assay development, candidate profiling, and translational pharmacology activities.
• Develop biomarker strategies, translational packages, and pharmacology plans supporting proof-of-mechanism and proof-of-concept studies.
• Guide the application of human disease models, pharmacodynamic biomarkers, and Pharmacokinetics/Pharmacodynamics (PK/PD) frameworks to support dose selection and patient stratification.
• Integrate receptor pharmacology, G protein-coupled receptor (GPCR) biology, cell signaling, and translational science to maximize probability of technical and clinical success.
• Collaborate closely with Discovery, DPDS, Biomarkers, Clinical Pharmacology, Quantitative Sciences, Translational Medicine, Regulatory, and external partners.
• Provide scientific mentorship and leadership across matrix teams.
• Foster a culture of innovation, scientific excellence, accountability, collaboration, and patient-focused decision making.

Senior Principal Scientist, Aging and Metabolism

• Lead translational pharmacology activities across multiple Aging and Metabolism programs from target validation through candidate selection and early clinical translation.
• Drive scientific strategy and critical decision-making through integration of disease biology, pharmacology, biomarkers, human genetics, and clinical data.
• Contribute to portfolio prioritization, governance reviews, and evaluation of external innovation opportunities.
• Establish and manage collaborations with academic institutions, Contract Research Organizations (CROs), biotechnology companies, and other external partners.
• Present scientific strategies and recommendations to senior leadership and governance committees.
• Provide leadership for target validation, mechanism-of-action studies, assay development, candidate profiling, and translational pharmacology activities.
• Develop biomarker strategies, translational packages, and pharmacology plans supporting proof-of-mechanism and proof-of-concept studies.
• Guide the application of human disease models, pharmacodynamic biomarkers, and Pharmacokinetics/Pharmacodynamics (PK/PD) frameworks to support dose selection and patient stratification.
• Integrate receptor pharmacology, G protein-coupled receptor (GPCR) biology, cell signaling, and translational science to maximize probability of technical and clinical success.
• Serve as a subject matter expert, ensuring scientific rigor, quality, reproducibility, and translational relevance across programs.
• Collaborate closely with Discovery, DPDS, Biomarkers, Clinical Pharmacology, Quantitative Sciences, Translational Medicine, Regulatory, and external partners.
• Provide scientific mentorship and leadership across matrix teams.
• Foster a culture of innovation, scientific excellence, accountability, collaboration, and patient-focused decision making.

• Building a free, user-friendly web platform for researchers to upload memory responses
• Designing and building an interface that hosts multiple scoring models
• Curating datasets and fine-tuning language models for scoring
• Evaluating models' scores against expert ratings
• Administrative tasks and writing as necessary

Research Assistant

• Provide scientific leadership in the planning, execution, and data interpretation across multiple biologics discovery programs.
• Lead protein engineering strategies for various antigens and biologics (antibodies and multi-specifics) using experimental, computational and structural biology tools
• Design and oversee the protein production and detailed characterization processes to support projects across the Innovation portfolio
• Drive early-stage developability assessment workflows of biologics
• Support mechanisms of action studies through assay development
• Support the selection of lead molecules to advance pipeline programs.
• Critically evaluate scientific literature, synthesize novel hypotheses and design and integrate rigorous experimental strategies to test them.
• Communicate project progress and key findings effectively in cross-functional meetings, ensuring alignment with timelines in a fast-paced, dynamic environment.
• Foster a collaborative and accountable team culture, with a strong emphasis on scientific excellence and continuous improvement.

Principal Scientist, Protein Production – Engineering

• The Senior Principal Scientist will serve as a CMC Analytical Lead (CMC-AL) for drug candidates across all stages of development, as well as within the commercial product portfolio as needed.
• Collaborate across functions to identify critical quality attributes (CQAs) for drug substance and drug product and establish control strategies to ensure product quality.
• Drive analytical controls in alignment with ICH guidelines and global regulatory requirements.
• Lead analytical strategy development as a core member of cross-functional CMC teams.
• Define product critical quality attributes and establish methods, specifications, and analytical control strategies.
• Collaborate across Analytical, Drug Substance, Drug Product, Quality, and Regulatory functions.
• Review, interpret, and communicate analytical results and conclusions.
• Author, review, and approve technical reports to support regulatory submissions.
• Respond to regulatory authority questions related to analytical strategy and data.
• Provide leadership, coaching, and mentoring to scientific staff within matrix teams.

Senior Principal Scientist, Analytical Chemistry

• Design and train large-scale transformer and hybrid foundation models
• Own model architecture choices across text, multimodal, and emerging paradigms
• Diagnose and resolve training instabilities at scale
• Navigate scaling tradeoffs across data, compute, and architecture
• Define the technical direction for next-generation models
• Apply strong fundamentals in deep learning and representation learning
• Design and modify transformer architectures, including: Attention variants, RoPE, ALiBi, Grouped Query Attention (GQA), Mixture-of-Experts (MoE)
• Build models from first principles, not just adapt pre-existing codebases
• Own optimizer and scheduler choices, including: AdamW, Lion, Adafactor
• Understand and debug optimizer instability, gradient pathologies, divergence at large scale
• Validate scaling laws and navigate compute vs. data tradeoffs

Senior Principal Software Scientist

• Set technical direction for core replenishment R&D — define the modeling roadmap across demand forecasting, inventory optimization, and decision-making policy, and align it with product and business strategy.
• Model complex problems such as inventory decay, promotions, price elasticity, and inventory uncertainty, and implement solutions to multi-stage and multi-echelon inventory optimization problems.
• Drive fundamental changes to our core system from research through production, writing rigorously tested and scalable code.
• Lead research and development for new product and business challenges.
• Raise the technical bar across the Intelligence team: mentor scientists and engineers, set standards for experimental rigor, and review designs and results.
• Push the boundaries of AI capabilities in both products and scientist workflows.

Staff Applied Scientist – Distribution Center

• Lead end-to-end AI applications on trial imaging data (CT, MRI, PET) for quantitative imaging measures and AI-derived endpoints
• Collaborate internally and externally to drive scientific innovation in foundational imaging AI that are relevant to oncology drug development — including automated segmentation, radiomics, and multimodal predictive modeling through hands-on research
• Translate imaging-derived evidence into actionable insights by converting complex quantitative findings into clear scientific narratives and engaging cross-functional stakeholders
• Provide scientific leadership to external partnerships — including imaging AI vendors, CROs, biomarker companies, academic centers, and imaging OEMs — to accelerate model development, validation, and deployment
• Publish and present scientific innovation at top scientific and clinical conferences (e.g., MICCAI, AACR, RSNA, etc.)

Principal Scientist, Imaging Analytics

• Lead end-to-end AI applications on trial imaging data (CT, MRI, PET) for quantitative imaging measures and AI-derived endpoints.
• Collaborate internally and externally to drive scientific innovation in foundational imaging AI that are relevant to oncology drug development — including automated segmentation, radiomics, and multimodal predictive modeling through hands-on research.
• Translate imaging-derived evidence into actionable insights by converting complex quantitative findings into clear scientific narratives and engaging cross-functional stakeholders.
• Provide scientific leadership to external partnerships — including imaging AI vendors, CROs, biomarker companies, academic centers, and imaging OEMs — to accelerate model development, validation, and deployment.
• Publish and present scientific innovation at top scientific and clinical conferences (e.g., MICCAI, AACR, RSNA, etc.)

• Responsible for the administrative aspects of CHEER’s programs, including: managing program records and handling communication needs of the program.
• Provides assistance in the development of reports, presentations, and data analysis.
• Assists in data collection and provides feedback on progress.
• Schedules meetings with program participants; conducts reminder communications.
• Reviews the data collection forms for programs; checks work of junior staff performing data entry to ensure timely and accurate entry.
• Provides technical guidance to junior staff.
• Conducts literature searches.
• Assists Investigators with manuscript and presentation preparation and research.
• Participates in staff meetings/initiatives including appropriate quality improvement and education activities, or if unable to attend non-mandatory activities, accepts responsibility to review meeting minutes and becomes knowledgeable of issues discussed.
• Performs office-related duties such as answering phones, managing email accounts, picking up and delivering mail, ordering and distributing office supplies, handling faxes, scanning, filing, photocopying, collating materials, maintaining the update of policy manuals, etc.

Research Assistant, Pediatrics

• Assists with data collection by conducting clinical interviews and administering surveys
• Participant scheduling and correspondence
• Reviewing recorded clinical interviews
• Attending team meetings
• Recruitment of individuals with PTSD
• Data collection through interviews, surveys, and electronic medical record data extraction
• Coordination of study visits and meetings associated with conduct of a clinical trial study
• Collaborate with a multidisciplinary team across primary care and psychiatry

Research Assistant, Psychiatry – Per Diem

• Design and execute mixed-method research studies (surveys, interviews, usability testing, field observations, diary studies, etc.) that adhere to best practices
• Conduct foundational research to understand user behaviors, needs, and motivations
• Lead the recruiting of diverse, representative participant samples
• Select and manage research vendors to ensure study outputs meet team and stakeholder expectations
• Analyze research data to identify patterns and actionable insights; synthesize findings into clear, decision-ready reports and presentations
• Create customer journey maps, personas, use scenarios, and other synthetic frameworks that enable team members to understand customer needs, behaviors, and wants
• Scope experience opportunities, conduct benchmarking, and frame CX/UX problems to inform digital experience strategies
• Support strategy activation by defining MVP experiences and prioritizing initiatives for implementation
• Present findings and strategic recommendations in a compelling, storytelling manner to internal audiences, including senior leadership
• Facilitate workshops, ideation sessions, and empathy exercises to build group consensus and enable evidence-based decision making
• Collaborate cross-functionally with designers, product owners, and other internal stakeholders to integrate research findings into product and experience decisions

Senior Digital Consumer Experience Researcher

• Set technical direction for core replenishment R&amp;D.
• Model complex problems such as inventory decay, promotions, price elasticity, and inventory uncertainty.
• Drive fundamental changes to our core system from research through production.
• Lead research and development for new product and business challenges.
• Mentor scientists and engineers, set standards for experimental rigor.

Staff Applied Scientist

• Lead a team in the development and execution of health economic and modeling strategies to support the value of the Company’s oncology portfolio
• Provide leadership, mentorship, and strategic direction to a team of 3–4 health economists
• Oversee the prioritization and development of high-quality global health economic models and tools to support market access, pricing, reimbursement, HTA submissions, and formulary decision-making across U.S. and international markets
• Collaborate with key countries and the regional team to adapt global models for local HTA, reimbursement, and formulary submissions
• Generate and communicate early health economic insights to inform development and commercialization strategies
• Build strong partnerships with internal stakeholders to ensure modeling strategies align and support the overall product development and value evidence strategy and implementation
• Develop and maintain relationships with external thought leaders in health economics, decision sciences, and health policy to enhance scientific credibility, inform strategy, and position our company as a leader in the field

Senior Principal Scientist, Outcomes Research

• Design, develop, and maintain geometry processing and simulation algorithms for engineering applications.
• Build services for reading, processing, and writing 2D/3D engineering data.
• Develop rendering modules for generating 2D/3D visual assets.
• Curate and manage large-scale datasets for learning-based systems.
• Implement and optimize post-training workflows for machine learning models.
• Contribute to the development of domain-specific languages for engineering tasks.

Research Scientist – Geometry, Machine Learning

• Independently build, align, and execute technical plans to achieve objectives across multiple programs
• Timely delivery of hands-on data analysis, visualization, and interpretation for Discovery portfolio decision-making
• Substantially impact Discovery programs through direct technical execution and indirect contribution as a member of Discovery project teams
• Collaborate with cross-functional teams to drive computational insights for Discovery programs

Research Scientist jobs in Massachusetts

See all jobs on JobTailor

Principal Scientist, Spatial Omics

Research Assistant II

Senior QEC Researcher – Integrated HPC & Quantum Solutions

Senior Principal Scientist, Aging and Metabolism

Senior Principal Scientist, Aging and Metabolism

Research Assistant

Principal Scientist, Protein Production – Engineering

Senior Principal Scientist, Analytical Chemistry

Senior Principal Software Scientist

Staff Applied Scientist – Distribution Center

Principal Scientist, Imaging Analytics

Principal Scientist, Imaging Analytics

Research Assistant, Pediatrics

Research Assistant, Psychiatry – Per Diem

Senior Digital Consumer Experience Researcher

Staff Applied Scientist

Senior Principal Scientist, Outcomes Research

Research Scientist – Geometry, Machine Learning

Principal Scientist, Computational-Immunology Discovery

Principal Scientist, Computational-Immunology Discovery