Clinical Project Manager II – Early Phase Oncology

Syneos Health

Clinical Project Manager II driving execution of Early Phase Oncology trials at Syneos Health. Managing all operational aspects and ensuring timely delivery of key milestones in a fast-paced team environment.

Posted 6/20/2026full-timeFoster City • California • 🇺🇸 United StatesMid-LevelSenior💰 $95,000 - $175,700 per yearWebsite

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Drive operational execution of Early Phase Oncology clinical trials from study start-up through database lock and closeout
Independently manage day-to-day study operations with minimal oversight
Own timelines, deliverables, risks, and issue resolution across multiple workstreams
Maintain deep operational awareness across all aspects of the trial — this is a role for someone comfortable working "in the weeds"
Ensure study milestones stay on track in a fast-paced environment with shifting priorities and competing demands
Partner cross-functionally to proactively identify risks, remove roadblocks, and implement operational solutions quickly
Support operational activities associated with dose escalation cohorts, dose expansion cohorts, safety review meetings, protocol amendments, enrollment management, and study execution activities
Monitor enrollment, site performance, data quality, and operational metrics to support successful study execution
Drive accountability across study teams to ensure timelines and deliverables are met
Lead vendor management activities and maintain strong oversight of external partners and CROs
Contribute to RFP development, vendor selection, and ongoing vendor performance management
Hold vendors accountable to timelines, deliverables, quality expectations, and issue resolution
Actively manage operational follow-through rather than relying solely on escalation pathways
Partner closely with CROs, monitoring teams, central laboratories, imaging vendors, and specialty oncology service providers
Lead cross-functional meetings with clear agendas, action-oriented discussions, and strong follow-up
Drive accountability across internal teams and external partners
Build strong collaborative relationships while effectively navigating challenging conversations and competing priorities
Mentor or support junior team members as needed
Operate confidently within a matrixed global environment with multiple stakeholders
Draft, review, and coordinate key study documents including protocols, informed consents, monitoring plans, investigator brochures, clinical study reports, and other essential study documentation
Support study budget tracking, forecasting, and operational planning activities
Review data listings and support interim and final reporting activities
Train CROs, investigators, study coordinators, and vendors on protocol and study requirements
Support inspection readiness activities and maintain compliance with GCP, ICH, and applicable regulatory requirements
Contribute to SOP development, process improvement initiatives, and operational best practices

Requirements

What you’ll need

3+ years of Clinical Project Management experience within clinical research
Experience independently managing clinical trials from study start-up through closeout
Direct Oncology clinical trial experience
Direct Early Phase Oncology clinical trial experience supporting Phase I, Phase Ib, and/or Phase II studies
Strong understanding of the unique operational requirements associated with Early Phase Oncology programs
Experience supporting dose escalation and/or dose expansion studies
Strong CRO/vendor management and oversight experience
Proven ability to independently drive study execution in fast-paced clinical environments
Experience managing cross-functional clinical trial activities within matrixed organizations
Comfortable balancing strategic oversight with hands-on operational execution

Benefits

Comp & perks

Health benefits to include Medical, Dental and Vision
Company match 401k
Eligibility to participate in Employee Stock Purchase Plan
Eligibility to earn commissions/bonus based on company and individual performance
Flexible paid time off (PTO) and sick time

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

Clinical Project ManagementOncology clinical trialsEarly Phase Oncology trialsDose escalation studiesDose expansion studiesGCP complianceICH complianceOperational planningData quality monitoringVendor management

Soft Skills

LeadershipCollaborationProblem-solvingCommunicationMentoringAccountabilityAdaptabilityOrganizational skillsStakeholder managementConflict resolution