eCOA Project Manager

Syneos Health

eCOA Project Manager leading RTSM/eCOA systems design and management for clinical trials at Syneos Health. Collaborates with clinical operations teams to ensure high-quality execution and compliance.

Posted 6/17/2026full-timeRemote • 🇺🇸 United StatesMid-LevelSenior💰 $114,000 - $210,900 per yearWebsite

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Lead the design, development, configuration, and lifecycle management of RTSM/IRT/eCOA systems
Partner closely with Clinical Operations and study teams to understand protocol requirements and ensure alignment on timelines, scope, and deliverables
Develop and maintain User Requirement Specifications (URS) and system design documentation
Serve as the primary operational point of contact for RTSM activities across assigned studies
Provide ongoing RTSM/eCOA expertise throughout the entire study lifecycle
Lead User Acceptance Testing (UAT) activities and validation efforts
Ensure completion, review, and filing of testing and validation documentation
Oversee quality reviews and approval of validation documentation
Collaborate with vendors and study teams to identify, investigate, and resolve system issues
Manage emergency changes and change control activities
Act as the liaison between Clinical Operations, RTSM/eCOA vendors, and internal stakeholders
Drive accountability for vendor deliverables and timelines
Facilitate effective communication across matrixed teams
Support issue escalation and resolution activities
Ensure RTSM processes align with SOPs, regulatory requirements, and quality standards
Support inspection readiness initiatives
Identify process gaps and implement continuous improvement opportunities
Develop standardized RTSM workflows and supporting guidance documents
Ensure consistent execution across studies
Manage RTSM user access requests, modifications, and removals
Oversee periodic access reviews and audit readiness activities
Develop and maintain role-based RTSM training materials
Ensure training aligns with system functionality and regulatory expectations

Requirements

What you’ll need

Bachelor's degree required (BA/BS)
Minimum of 5 years of operational experience within clinical trials in a pharmaceutical company and/or CRO environment
Deep expertise in RTSM/IRT (IVRS/IWRS) systems and working knowledge of eCOA platforms
End-to-end experience managing RTSM system builds, updates, and implementations
Proven experience leading User Acceptance Testing (UAT) and validation activities
Hands-on experience working directly with RTSM/eCOA vendors
Vendor management experience within clinical research environments
Project management experience supporting complex, matrixed studies or programs
Strong understanding of the end-to-end clinical trial process
Familiarity with testing and issue-tracking tools
Knowledge of GCP principles and applicable regulatory requirements
Experience supporting inspection readiness activities
Understanding of SOP compliance and system security controls

Benefits

Comp & perks

Health benefits to include Medical, Dental and Vision
Company match 401k
Eligibility to participate in Employee Stock Purchase Plan
Eligibility to earn commissions/bonus based on company and individual performance
Flexible paid time off (PTO) and sick time
Company car or car allowance

ATS Keywords

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Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools

RTSMIRTeCOAUser Acceptance Testingvalidationsystem design documentationUser Requirement Specificationsproject managementclinical trial processGCP principles

Soft Skills

communicationcollaborationleadershipproblem-solvingaccountabilitycontinuous improvementtraining developmentissue escalationvendor managementmatrixed team facilitation

Certifications

Bachelor's degree