Senior Site Activation Manager – Sponsor-Dedicated

Syneos Health

Senior Site Activation Manager leading site activation strategy in the US for Syneos Health. Collaborating with clinical teams to optimize processes and timelines.

Posted 5/1/2026full-timeRemote • Arizona, California, Maine, Ohio, Rhode Island • 🇺🇸 United StatesSeniorWebsite

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Drive global site start-up strategy and execution from site identification through activation and lifecycle maintenance
Own SSU timelines, forecasts, and delivery against contracted milestones
Identify risks early (regulatory, enrollment, timelines) and implement mitigation plans
Lead all start-up deliverables, including:
Site identification and feasibility
Regulatory submissions and lifecycle maintenance (amendments, HA/EC communications, licenses)
CTA and investigator budget negotiation/execution
Essential document collection and TMF readiness
Ensure delivery aligns with SOPs, sponsor expectations, and quality standards
Act as a key interface with sponsor stakeholders, presenting strategy, risks, and status
Partner across Clinical Ops, PM, Contracts, Data Management, Medical Writing, and SSU Country teams
Collaborate within a team-first, highly accountable FSP environment
Review SSU budgets vs. milestones and support profitability targets
Track and manage out-of-scope activities in partnership with PM/SSU leadership
Oversee preparation of core submission documents and amendment dossiers
Conduct Regulatory Impact Assessments and communicate risks
Support development of SIS/ICF documents and country-specific submissions
Contribute to process creation and refinement as the team scales
Operate effectively in a setting where execution and process development happen in parallel

Requirements

What you’ll need

Minimum 3 years prior experience as a Site Activation Manager (SAM)
Minimum of 2 years' experience in Managing large scale, US-based Site Activation with high success
Strong track record delivering SSU activities across Phase II–IV trials
Solid understanding of ICH-GCP, regulatory pathways, and start-up processes
Demonstrated ability to manage multiple studies and competing priorities
Strong communication, stakeholder management, and problem-solving skills
Highly Preferred FSP (Functional Service Provider) experience
Prior Global SAM responsibility (regional experience considered with strong performance, if US based sites)
Experience integrating Syneos and sponsor systems
Proven ability to operate in ambiguity and help build processes while delivering
Track record of high performance and readiness for increased scope/visibility

Benefits

Comp & perks

Health benefits to include Medical, Dental and Vision
Company match 401k
Eligibility to participate in Employee Stock Purchase Plan
Eligibility to earn commissions/bonus based on company and individual performance
Flexible paid time off (PTO) and sick time

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

site start-up strategyregulatory submissionsbudget negotiationTMF readinessRegulatory Impact AssessmentsSIS/ICF document developmentPhase II trialsPhase III trialsPhase IV trialsprocess creation

Soft Skills

communicationstakeholder managementproblem-solvingteam collaborationaccountabilityrisk managementtime managementadaptabilityprioritizationleadership

Certifications

ICH-GCP certification