Clinical Trial Manager – US

Syneos Health

Clinical Trial Manager overseeing global clinical trials with operational leadership and high-quality standards at Syneos Health. Accelerating the delivery of life-changing therapies globally.

Posted 4/15/2026full-timeRemote • Arizona, Maine, Ohio, Rhode Island • 🇺🇸 United StatesJuniorMid-Level💰 $132,000 - $178,000 per yearWebsite

Tech Stack

Tools & technologies

Google Cloud Platform

About the role

Key responsibilities & impact

Lead end-to-end clinical trial execution, ensuring delivery against timelines, quality standards, and budget
Provide operational oversight of site management and monitoring activities, including on-site and centralized monitoring
Identify, assess, and proactively mitigate clinical and operational risks using a risk-based management approach (RACT)
Serve as the primary escalation point for CRAs, investigative sites, and cross-functional stakeholders
Partner closely with Study Start-Up, Data Management, Biostatistics, Safety, and Patient Recruitment teams to drive milestone achievement
Leverage integrated systems and data (CTMS, EDC, ePRO, TMF, dashboards) to monitor performance, trends, and risk indicators
Ensure ongoing inspection readiness and compliance with ICH-GCP, SOPs, and global regulatory requirements
Lead study-specific training and foster alignment across the clinical trial team
Review metrics and operational data to anticipate challenges and implement timely solutions
Mentor and support CRAs, contributing to a culture of accountability, continuous improvement, and collaboration

Requirements

What you’ll need

Hands-on Clinical Research Associate (CRA) experience, including on-site monitoring (not remote-only)
2+ years of experience as a Clinical Trial Manager, preferably within a CRO environment
Strong understanding of global clinical trial operations and site management

Benefits

Comp & perks

company car or car allowance
Health benefits to include Medical, Dental and Vision
Company match 401k
eligibility to participate in Employee Stock Purchase Plan
Eligibility to earn commissions/bonus based on company and individual performance
flexible paid time off (PTO) and sick time

ATS Keywords

✓ Tailor your resume

Applicant Tracking System Keywords

Tip: use these terms in your resume and cover letter to boost ATS matches.

Hard Skills & Tools

clinical trial executionsite managementmonitoring activitiesrisk-based managementstudy-specific trainingoperational data reviewclinical research associate experienceclinical trial managementglobal clinical trial operations

Soft Skills

operational oversightproblem-solvingmentoringcollaborationcommunicationaccountabilitycontinuous improvementstakeholder management