Senior Payroll and Accounting Specialist

Spyre Therapeutics

Senior Payroll and Accounting Specialist at Spyre Therapeutics, responsible for payroll administration and equity management. Ensuring compliance with tax regulations and SOX procedures while supporting company growth.

Posted 5/29/2026full-timeRemote • 🇺🇸 United StatesSenior💰 $110,000 - $130,000 per yearWebsite

Tech Stack

Tools & technologies

ERP

About the role

Key responsibilities & impact

Manage the full-cycle payroll process, including data entry, tax withholdings, and benefits deductions, etc.
Ensure all payroll activities align with federal, state, and local tax regulations, including the proper handling of withholdings and filings.
Perform regular audits of payroll data and reconcile payroll bank accounts to ensure accuracy and identify discrepancies.
Coordinate with HR to ensure accurate deductions for health insurance, retirement plans (401k), and other voluntary benefits.
Act as the primary point of contact for staff regarding pay-related inquiries, resolving issues related to paychecks or tax forms with high confidentiality.
Identify opportunities to streamline payroll workflows and improve the efficiency of the payroll software or HRIS.
Prepare and post monthly journal entries for payroll accruals, benefits, taxes, and other standard corporate expenses.
Maintain T&E system including syncing to the Company’s ERP and reviewing expense transactions for compliance with Company policies.
Assist in the preparation of monthly and quarterly financial statements by ensuring all payroll-related expenses are accurately categorized.
Maintain and document internal controls (such as SOX compliance procedures) to ensure the integrity of financial reporting and prevent fraud.
Facilitate the issuance of new equity awards (RSUs, Stock Options, or ESPP) by ensuring all grant agreements are properly executed and recorded in the equity platform.
Monitor vesting schedules and process stock option exercises, ensuring the accurate flow of data between the equity platform and payroll for tax withholding.
Other duties as assigned.

Requirements

What you’ll need

Bachelor’s degree in Accounting or related field
5+ years of payroll and accounting experience
Experience managing payroll and tax withholdings across multiple states. Experience with international locations is a plus.
Proficiency in payroll/HRIS and equity management platforms (i.e. Rippling, Fidelity, E*TRADE)
Solid understanding of the lifecycle of various equity vehicles, including RSUs, NSOs, ISOs, and ESPPs.
A proven track record of handling highly sensitive executive compensation and employee financial data with total discretion.
Excellent organizational, analytical, prioritization and problem-solving skills in an environment of high volume of projects; detail-oriented
Possesses a professional demeanor, discretion and judgment
Ability to work effectively and establish and promote positive relationships
Self-starter who possesses initiative and ability to work alone while capable of driving business results without significant supervision
Must have schedule flexibility to meet the demands of monthly and quarterly close
Excellent verbal and written communication skills
Ability to work effectively with all employee levels and external contacts.

Benefits

Comp & perks

Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly.
Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
Unlimited PTO
Two, one-week company-wide shutdowns each
Commitment to provide professional development opportunities.
Remote working environment with frequent in-person meetings to address complex problems and build relationships.

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

payroll processingtax withholdingsbenefits deductionspayroll auditsfinancial statement preparationequity managementdata entryaccount reconciliationinternal controlsSOX compliance

Soft Skills

organizational skillsanalytical skillsproblem-solving skillsattention to detaildiscretionjudgmentrelationship buildingself-starterinitiativecommunication skills

Certifications

Bachelor’s degree in Accounting