Principal Scientist – Quantitative Translational Scientist

Regeneron

Principal Scientist developing quantitative biomarker strategies and analyses for Regeneron’s Oncology portfolio. Collaborating with teams to assure data integrity and drive Precision Medicine objectives.

Posted 4/29/2026full-timeArmonk • New York • 🇺🇸 United StatesLead💰 $128,600 - $210,000 per yearWebsite

Tech Stack

Tools & technologies

AWSAzureCloudGoogle Cloud PlatformLinuxShell Scripting

About the role

Key responsibilities & impact

Set and refine quantitative biomarker strategies across multiple programs, aligning with Precision Medicine Strategy Leads and senior stakeholders.
Translate program objectives into testable hypotheses, analytical roadmaps, and decision criteria that inform clinical development and asset strategy.
Architect exploratory analyses of multi-modal datasets (genomic, transcriptomic, proteomic, metabolomic, clinical, and other biomarkers) to generate actionable insights.
Define and review statistical frameworks, including hypothesis testing, modeling approaches, and power/sample-size analyses, ensuring appropriate interpretation.
Oversee the correct application of statistical models on integrated datasets and drive clear, decision-oriented interpretation for translational and clinical teams.
Contribute to the vision for scalable, reproducible pipelines and automated workflows that support enterprise-wide biomarker discovery and clinical development.
Direct the design and enhancement of computational workflows for novel biomarkers; evaluate, integrate, or build tools as needed.
Provide guidance on data cleaning, integration, and visualization standards to enable robust, interpretable analyses.

Requirements

What you’ll need

Proficient in statistical modeling/regression, machine learning, and related data integration/blending techniques.
Experienced in implementing scalable workflows on cloud platforms (AWS, GCP, or Azure)
Experienced in Linux and/or cloud environments, shell scripting, and notebook-based workflows.
Knowledgeable of structured data and data mapping for systems integration, data provisioning, and consumption.
Experience with version control and AI coding assistants such as Claude Code is strongly preferred.
To be considered for this role, you must have at minimum a PhD with 2 years, or Masters with 5 years of relevant industry experience in one of the following or otherwise related quantitative fields: Computer Science, Computational Biology, Systems Biology, Quantitative Biology, Bioinformatics, Data Analytics, Biostatistics.

Benefits

Comp & perks

health and wellness programs (including medical, dental, vision, life, and disability insurance)
fitness centers
401(k) company match
family support benefits
equity awards
annual bonuses
paid time off
paid leaves (e.g., military and parental leave) for eligible employees at all levels!

ATS Keywords

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Applicant Tracking System Keywords

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Hard Skills & Tools

statistical modelingregressionmachine learningdata integrationdata blendingdata cleaningdata visualizationcomputational workflowshypothesis testingpower/sample-size analysis

Soft Skills

communicationcollaborationdecision-makingleadershipproblem-solving

Certifications

PhDMasters